1-Buten-3-one, 1-amino-4,4,4-trifluoro-1-phenyl- | 106578-65-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 1-Buten-3-one, 1-amino-4,4,4-trifluoro-1-phenyl-
• 英文别名: (Z)-4-amino-1,1,1-trifluoro-4-phenylbut-3-en-2-one
• CAS: 106578-65-8
• 化学式: C₁₀H₈F₃NO
• 分子量: 215.175
• InChiKey: PRDFATFVFRBFGR-VURMDHGXSA-N

物化性质

• 沸点：
  237.0±40.0 °C(Predicted)
• 密度：
  1.284±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  43.1
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1-Buten-3-one, 1-amino-4,4,4-trifluoro-1-phenyl- 在 氨 作用下， 以 乙醇 为溶剂， 反应 20.0h， 生成 (Z)-1,1,1-trifluoro-4-(methylamino)-4-phenylbut-3-en-2-one
  参考文献：
  名称：

  Interaction of fluorine-containing ?-aminovinyl ketones with amines

  摘要：

  DOI：

  10.1007/bf00953227
• 作为产物：
  描述：

  1,1,1-trifluoro-4-methylsulfanyl-4-phenylbut-3-en-2-one 在 ammonium hydroxide 作用下， 以 乙腈 为溶剂， 以88%的产率得到1-Buten-3-one, 1-amino-4,4,4-trifluoro-1-phenyl-
  参考文献：
  名称：

  O-N, S-N and N-N exchange reactions at olefinic carbon atoms: Facile synthetic method for β-trifluoroacetylvinylamines

  摘要：

  DOI：

  10.1016/s0040-4039(01)93334-9

文献信息

• Interaction of fluoroalkyl-containing ?-diketones with amines
  作者：V. I. Filyakova、Y. G. Ratner、N. S. Karpenko、K. I. Pashkevich

  DOI：10.1007/bf01430731

  日期：1996.9

  The composition of products of the interaction of asymmetric fluoroalkyl-containing beta-diketones with amines was studied. Mixtures of regioisomeric beta-aminovinylketones and products of cleavage and secondary condensation are formed, depending on the temperature, the solvent, the nature of the fluorinated and nonfluorinated substituents in the beta-diketone, and the basicity of the amine. The major product is a beta-aminovinylketone in which the NH2 group is removed from the fluoroalkyl substituent. No beta-aminovinylimines, products of condensation involving two electrophilic centers, were observed.
• Karpenko; Filyakova; Pashkevich, Russian Journal of Organic Chemistry, 1997, vol. 33, # 12, p. 1724 - 1726
  作者：Karpenko、Filyakova、Pashkevich

  DOI：——

  日期：——
• Hydrolysis of fluoroalkyl-containing ?-aminovinyl ketones
  作者：L. N. Bazhenova、V. I. Filyakova、V. E. Kirichenko、K. I. Pashkevich

  DOI：10.1007/bf00957999

  日期：1991.3

  The kinetics of hydrolysis of fluoroalkyl-containing beta-aminovinyl ketones R1C(O)CHC(NHR3)R2, in which the substituents CF3 and HCF2CF2 are in the ketone (R1) or enamine parts of the molecule (R2), was studied. In acid (pH < 5) and alkaline (pH > 10) media, they hydrolyze with the formation of the corresponding amines and beta-diketones. In an alkaline medium, the beta-diketones undergo cleavage to fluorinated acids and methyl ketones. The rate constants of hydrolysis in an acid medium change within a range of four orders, depending on the nature of the substituents. The presence of a fluoroalkyl group at the enamine reaction center increases the hydrolysis rate. In an alkaline medium, the rate constants vary within one order.
• Exchange reaction between fluorine-containing ?-diketones and ?-aminovinylketones
  作者：V. I. Filyakova、K. I. Pashkevich

  DOI：10.1007/bf00953748

  日期：1989.1
• HOJO, MASARU;MASUDA, RYOICHI;OKADA, ETSUJI;SAKAGUCHI, SYUHEI;NARUMIYA, HI+, TETRAHEDRON LETT., 30,(1989) N5, C. 6173-6176
  作者：HOJO, MASARU、MASUDA, RYOICHI、OKADA, ETSUJI、SAKAGUCHI, SYUHEI、NARUMIYA, HI+

  DOI：——

  日期：——