1,3-dimethyl-1H-imidazo[4,5-c]quinolin-2(3H)-one | 1448352-04-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1,3-dimethyl-1H-imidazo[4,5-c]quinolin-2(3H)-one
• 英文别名: 1,3-Dimethylimidazo[4,5-c]quinolin-2-one；1,3-dimethylimidazo[4,5-c]quinolin-2-one
• CAS: 1448352-04-2
• 化学式: C₁₂H₁₁N₃O
• 分子量: 213.239
• InChiKey: HQYQBCAXIWSPST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  36.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  (±)-(R,S)-1,3-dimethyl-3,3a,4,5-tetrahydro-1H-imidazo[4,5-c]quinolin-2(9bH)-one 在 叔丁基过氧化氢 、 potassium iodide 作用下， 以 水 、 乙腈 为溶剂， 反应 4.0h， 以50%的产率得到1,3-dimethyl-1H-imidazo[4,5-c]quinolin-2(3H)-one
  参考文献：
  名称：

  FeCl₃-Catalyzed Cascade Cyclization in One Pot: Synthesis of Ring-Fused Tetrahydroquinoline Derivatives from Arylamines and N-Substituted Lactams

  摘要：

  Multiple cross-dehydrogenative-coupling reactions catalyzed by FeCl3 in one pot were developed. Arylamines and N-substituted lactams were reacted, and ring-fused tetrahydroquinoline derivatives were formed by two C-C bonds and one C-N bond formation as well as one C-N bond cleavage. The lactams were also used as solvent.

  DOI：

  10.1021/jo400979h

文献信息

• FeCl₃-Catalyzed Cascade Cyclization in One Pot: Synthesis of Ring-Fused Tetrahydroquinoline Derivatives from Arylamines and <i>N</i>-Substituted Lactams
  作者：Manman Sun、Tianshui Zhang、Weiliang Bao

  DOI：10.1021/jo400979h

  日期：2013.8.16

  Multiple cross-dehydrogenative-coupling reactions catalyzed by FeCl3 in one pot were developed. Arylamines and N-substituted lactams were reacted, and ring-fused tetrahydroquinoline derivatives were formed by two C-C bonds and one C-N bond formation as well as one C-N bond cleavage. The lactams were also used as solvent.