phenyl-[(1R,2R)-2-[4-(trifluoromethyl)phenyl]cyclopropyl]methanone | 1021868-07-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: phenyl-[(1R,2R)-2-[4-(trifluoromethyl)phenyl]cyclopropyl]methanone
• CAS: 1021868-07-4
• 化学式: C₁₇H₁₃F₃O
• 分子量: 290.285
• InChiKey: FJOUHBDUESDIFZ-LSDHHAIUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  对三氟甲基苯乙烯 、 2-二氮杂-1-苯乙酮 在 吡啶 、 Halterman iron porphyrin 作用下， 以 氯仿 为溶剂， 生成 cis-1-benzoyl-2-(p-trifluoromethylphenyl)cyclopropane 、 trans-1-benzoyl-2-(p-trifluoromethylphenyl)cyclopropane 、 phenyl-[(1R,2R)-2-[4-(trifluoromethyl)phenyl]cyclopropyl]methanone
  参考文献：
  名称：

  Asymmetric intermolecular cyclopropanation of alkenes by diazoketones catalyzed by Halterman iron porphyrins

  摘要：

  The asymmetric addition of diazoacetophenone to styrene derivatives to give optically active cyclopropyl ketones (ee up to 80%) was carried out rising chiral iron porphyrins as homogeneous catalysts. Intermolecular N-H functionalization of anilines by means of carbenoid-induced N-H insertion was also possible but without enantioselectivity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.06.131

文献信息

• Asymmetric intermolecular cyclopropanation of alkenes by diazoketones catalyzed by Halterman iron porphyrins
  作者：Irène Nicolas、Thierry Roisnel、Paul Le Maux、Gérard Simonneaux

  DOI：10.1016/j.tetlet.2009.06.131

  日期：2009.9

  The asymmetric addition of diazoacetophenone to styrene derivatives to give optically active cyclopropyl ketones (ee up to 80%) was carried out rising chiral iron porphyrins as homogeneous catalysts. Intermolecular N-H functionalization of anilines by means of carbenoid-induced N-H insertion was also possible but without enantioselectivity. (C) 2009 Elsevier Ltd. All rights reserved.