N-methoxyquinoline hexafluorophosphate | 224768-68-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-methoxyquinoline hexafluorophosphate
• 英文别名: N-methoxyquinolinium hexafluorophosphate；1-Methoxyquinolin-1-ium;hexafluorophosphate
• CAS: 224768-68-7
• 化学式: C₁₀H₁₀NO*F₆P
• 分子量: 305.16
• InChiKey: BMKRPDRQRWKICD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.57
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  13.1
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  (R)-1-(3,3-dimethylbutyl)-4-hydroxy-1-methylnaphthalen-2(1H)-one 、 N-methoxyquinoline hexafluorophosphate 在 N,N-二异丙基乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以69%的产率得到
  参考文献：
  名称：

  Hepatitis C NS5B polymerase inhibitors: Functional equivalents for the benzothiadiazine moiety

  摘要：

  A series of quinoline derivatives was synthesized as potential bioisosteric replacements for the benzothiadiazine moiety of earlier Hepatitis C NS5B polymerase inhibitors. Several of these compounds exhibited potent activity in enzymatic and replicon assays. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.12.067

文献信息

• Hepatitis C NS5B polymerase inhibitors: Functional equivalents for the benzothiadiazine moiety
  作者：Douglas K. Hutchinson、Charles A. Flentge、Pamela L. Donner、Rolf Wagner、Clarence J. Maring、Warren M. Kati、Yaya Liu、Sherie V. Masse、Tim Middleton、Hongmei Mo、Debra Montgomery、Wen W. Jiang、Gennadiy Koev、David W.A. Beno、Kent D. Stewart、Vincent S. Stoll、Akhteruzzaman Molla、Dale J. Kempf

  DOI：10.1016/j.bmcl.2010.12.067

  日期：2011.3

  A series of quinoline derivatives was synthesized as potential bioisosteric replacements for the benzothiadiazine moiety of earlier Hepatitis C NS5B polymerase inhibitors. Several of these compounds exhibited potent activity in enzymatic and replicon assays. (C) 2011 Elsevier Ltd. All rights reserved.