(tert-Butyl)(2,2-dimethoxyethyl)amin | 92075-11-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (tert-Butyl)(2,2-dimethoxyethyl)amin
• 英文别名: tert-butyl-(2,2-dimethoxyethyl)amine；N-(2,2-dimethoxyethyl)-2-methylpropan-2-amine
• CAS: 92075-11-1
• 化学式: C₈H₁₉NO₂
• 分子量: 161.244
• InChiKey: FARSSNUMQTWXMH-UHFFFAOYSA-N

物化性质

• 沸点：
  174.5±20.0 °C(Predicted)
• 密度：
  0.883±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  30.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  (tert-Butyl)(2,2-dimethoxyethyl)amin 在 氨 、 溶剂黄146 、 mercury dichloride 作用下， 以 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 为溶剂， 反应 37.25h， 生成 N-(1-tert-butyl-1H-imidazol-2-yl)-N'-(3,4-dichlorophenyl)guanidine hydrochloride
  参考文献：
  名称：

  Antimalarial Activities of New Guanidylimidazole and Guanidylimidazoline Derivatives

  摘要：

  A series of new guanidylimidazole derivatives was prepared and evaluated in mice and Rhesus monkeys infected with malarial sporozoites. The majority of the new compounds showed poor metabolic stability and weak in vitro activities in three clones of Plasmodium falciparum. Compounds 8a, 8h, 9a, 16a, and 16e cured the mice infected with sporozoites of P. berghei at 160 and 320 mg/kg/day x 3 po. Compounds 8a showed better causal prophylactic activity than primaquine, tafenoquine, and Malarone in the Rhesus test. In the radical curative test, 8a cured one monkey and delayed relapse of another for 74 days at 30 mg/kg/day x 7 by im. By oral dosing, 8a delayed relapse 81 days for one and 32 days for other vs 11-12 days for control monkeys treated with 10 mg/kg of chloroquine by po alone. Compound 8h, which showed superior activity to 8a in mouse test, delayed the relapse of treated monkeys for 21-26 days at 30 mg/kg/day x 7 by oral.

  DOI：

  10.1021/jm200503s
• 作为产物：
  描述：

  N-tert-Butyl-N-(2,2-dimethoxyethyl)harnstoff 在 硫酸 作用下， 以 甲醇 、 水 为溶剂， 反应 12.0h， 以60%的产率得到(tert-Butyl)(2,2-dimethoxyethyl)amin
  参考文献：
  名称：

  Quast, Helmut; Nahr, Uwe, Chemische Berichte, 1984, vol. 117, # 8, p. 2761 - 2778

  摘要：

  DOI：

文献信息

• HYBRID BLOCK COPOLYMER MICELLES WITH MIXED STEREOCHEMISTRY FOR ENCAPSULATION OF HYDROPHOBIC AGENTS
  申请人：SILL Kevin N.

  公开号：US20080274173A1

  公开（公告）日：2008-11-06

  The present invention relates to the field of polymer chemistry and more particularly to multiblock copolymers and micelles comprising the same.

  本发明涉及聚合物化学领域，更具体地说是涉及多嵌段共聚物以及包含该共聚物的胶束。
• OUAST, H.;NAHR, U., CHEM. BER., 1984, 117, N 8, 2761-2778
  作者：OUAST, H.、NAHR, U.

  DOI：——

  日期：——
• Covalent modification of metal surfaces
  申请人：Breitenkamp Kurt

  公开号：US20080035243A1

  公开（公告）日：2008-02-14

  The present invention provides modified metal surfaces, methods of preparing the same, and intermediates thereto. These materials are useful in a variety of applications including biomaterials.
• ENCAPSULATED AMYLOID-BETA PEPTIDES
  申请人：Breitenkamp Kurt

  公开号：US20080274965A1

  公开（公告）日：2008-11-06

  The present invention relates to the field of polymer chemistry and more particularly to encapsulated peptides and uses thereof.
• ENCAPSULATED CONTRAST AGENTS
  申请人：Skaff Habib

  公开号：US20090092554A1

  公开（公告）日：2009-04-09

  The present invention relates to the field of polymer chemistry and more particularly to encapsulated contrast agents and methods for using the same.