1,1-difluoro-2-difluoromethoxypropane | 32778-16-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-difluoro-2-difluoromethoxypropane
• 英文别名: 2-difluoromethoxy-1,1-difluoroethane；(2.2-Difluor-ethyl)-difluormethyl-ether；2,2-Difluoroethyldifluoromethyl ether；2-(difluoromethoxy)-1,1-difluoroethane
• CAS: 32778-16-8
• 化学式: C₃H₄F₄O
• 分子量: 132.058
• InChiKey: RPVUQXHGCXIWHO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  8
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  1,1-difluoro-2-difluoromethoxypropane 在 氯 作用下， 生成 (+/-)-(1-Chlor-2.2-difluor-ethyl)-difluormethyl-ether
  参考文献：
  名称：

  全身麻醉剂。1.卤代甲基乙基醚作为麻醉剂。

  摘要：

  DOI：

  10.1021/jm00288a014
• 作为产物：
  描述：

  氟里昂-22 、 2,2-二氟乙醇 在 sodium hydroxide 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以36%的产率得到1,1-difluoro-2-difluoromethoxypropane
  参考文献：
  名称：

  Reactions of aliphatic fluoro-alcohols with CHClF2 at atmospheric pressure

  摘要：

  The reactions of aliphatic fluoro-alcohols with chlorodifluoromethane (CHCIF2) at atmospheric pressure were examined. In the reaction of CF3CF2CH2OH, the difluoromethylated ether was obtained in moderate yield by using ethers such as 1,4-dioxane, diglyme and THF, or their mixtures with water as a reaction solvent. While acetal and orthoformate were also produced, the selectivity of the difluoromethylated ether could be improved by adding water to the reaction. The effect of water could be explained by the reaction mechanism. (c) 2006 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jfluchem.2005.12.034

文献信息

• General anesthetics. 1. Halogenated methyl ethyl ethers as anesthetic agents
  作者：Ross C. Terrell、Louise Speers、Alex J. Szur、John Treadwell、Thomas R. Ucciardi

  DOI：10.1021/jm00288a014

  日期：1971.6
• Reactions of aliphatic fluoro-alcohols with CHClF2 at atmospheric pressure
  作者：Junji Mizukado、Yasuhisa Matsukawa、Heng-dao Quan、Masanori Tamura、Akira Sekiya

  DOI：10.1016/j.jfluchem.2005.12.034

  日期：2006.3

  The reactions of aliphatic fluoro-alcohols with chlorodifluoromethane (CHCIF2) at atmospheric pressure were examined. In the reaction of CF3CF2CH2OH, the difluoromethylated ether was obtained in moderate yield by using ethers such as 1,4-dioxane, diglyme and THF, or their mixtures with water as a reaction solvent. While acetal and orthoformate were also produced, the selectivity of the difluoromethylated ether could be improved by adding water to the reaction. The effect of water could be explained by the reaction mechanism. (c) 2006 Elsevier B.V. All rights reserved.