2,4-Bis(trifluoromethyl)-1,3-thiazole-5-carboxylic acid | 344744-10-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2,4-Bis(trifluoromethyl)-1,3-thiazole-5-carboxylic acid
• CAS: 344744-10-1
• 化学式: C₆HF₆NO₂S
• 分子量: 265.14
• InChiKey: SLGPRBIIGCUDMQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  16
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  10

反应信息

• 作为反应物：
  描述：

  2,4-Bis(trifluoromethyl)-1,3-thiazole-5-carboxylic acid 、 氯化亚砜 在 氮气 、 氯仿 作用下， 以 氯仿 、 N,N-二甲基甲酰胺 为溶剂， 反应 6.0h， 以to give 29.8 g (88.4% yield) product as a brown oil的产率得到2,4-bis-trifluoromethyl-thiazole-5-carboxylic acid chloride
  参考文献：
  名称：

  5-carboxanilido-2,4-bis-trifluoromethylthiazoles and their use to control rice blast

  摘要：

  本发明提供了5-羧基苯氨基-2,4-双三氟甲基噻唑及其组合物。这些化合物和组合物对植物上的真菌病具有有效的控制作用。它们特别有效地控制水稻稻瘟病。

  公开号：

  US06372769B1

文献信息

• Microbicidal salts of 5-carboxanilido-haloalkylthiazoles
  申请人：ROHM AND HAAS COMPANY

  公开号：EP1108714A1

  公开（公告）日：2001-06-20

  Compounds of the formula: wherein A is a strong base cation; R1 and R2 are independently (C1-C5)alkyl or (C1-C2)haloalkyl, provided that at least one of R1 and R2 is (C1-C2)haloalkyl; each R is independently halo, halo(C1-C5)alkyl, halo(C1-C5)alkoxy, nitro, cyano, pentahalosulfur, halomethylthio, haloethylthio, (C1-C2)alkylsulfinyl, halo(C1-C2)alkylsulfinyl, (C1-C2)alkylsulfonyl, or halo(C1-C2)alkylsulfonyl; and n is from one to five, are useful as fungicides, microbicides, marine antifoulants, and termiticides, compositions containing those compounds, and methods for their use.

  该化合物的化学式为：其中A是强碱性阳离子；R1和R2分别是独立的(C1-C5)烷基或(C1-C2)卤代烷基，但至少有一个是(C1-C2)卤代烷基；每个R独立地是卤素、卤代(C1-C5)烷基、卤代(C1-C5)氧基、硝基、氰基、五卤化硫、卤代甲硫基、卤代乙硫基、(C1-C2)烷基亚砜基、卤代(C1-C2)烷基亚砜基、(C1-C2)烷基磺酰基或卤代(C1-C2)烷基磺酰基；n为1至5，这些化合物可用作杀真菌剂、微生物杀剂、海洋防污剂和白蚁杀剂，还包括含有这些化合物的组合物以及它们的使用方法。
• Method to control termites
  申请人：Dow AgroSciences LLC

  公开号：US06423730B1

  公开（公告）日：2002-07-23

  The present invention relates to a method for controlling termites by treating the termites or the locus wherein the termites live, with a 5-carboxanilido-bis-trifluoromethyl-thiazole fungicide. This invention also relates to a method for controlling the damage caused by termites and to termite damage resistant articles.

  本发明涉及一种通过使用5-羧基苯胺基-双三氟甲基噻唑杀菌剂来处理白蚁或白蚁栖息地以控制白蚁的方法。本发明还涉及一种控制白蚁造成的损害的方法以及白蚁损害抗性物品。
• PROCESS FOR PREPARING THIAZOLECARBOXYLIC ACID CHLORIDES
  申请人：Mitsui Chemicals, Inc.

  公开号：EP0377750A1

  公开（公告）日：1990-07-18

  The invention provides a process for preparing thiazolecarboxylic acid chlorides represented by general formula (II) (wherein R1 represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group or a lower alkyl group substituted by a halogen atom or a lower alkoxy group, and R2 represents a hydrogen atom, a lower alkyl group optionally substituted by a halogen atom or a lower alkoxy group), which comprises reacting a thiazolecarboxylic acid represented by general formula (I) (wherein R1 and R2 are as defined above with respect to general formula (II) with phosgene or trichloromethyl chloroformate in the presence or absence of a catalyst.

  本发明提供了一种制备通式(II)代表的噻唑羧酸氯化物的工艺（其中R1代表氢原子、卤素原子、低级烷基、低级烷氧基或被卤素原子或低级烷氧基取代的低级烷基，R2代表氢原子、R1代表氢原子、低级烷基、低级烷氧基或被卤素原子或低级烷氧基取代的低级烷基，R2代表氢原子、低级烷基、低级烷氧基或被卤素原子或低级烷氧基取代的低级烷基），该反应包括在催化剂存在或不存在的情况下，将通式（I）代表的噻唑羧酸（其中 R1 和 R2 如上文通式（II）所定义）与光气或氯甲酸三氯甲酯反应。
• 5-Carboxanilido-haloalkylthiazoles as antimicrobial and marine antifouling agents
  申请人：ROHM AND HAAS COMPANY

  公开号：EP1110454A2

  公开（公告）日：2001-06-27

  The present invention relates to a method for inhibiting the growth of microorganisms and marine organisms at a locus. In particular, the present invention relates to the use of certain 5-carboxanilido-haloalkylthiazoles as antimicrobial and marine antifouling agents.

  本发明涉及一种抑制微生物和海洋生物在某处生长的方法。特别是，本发明涉及某些 5-甲酰苯胺-卤代烷基噻唑作为抗菌剂和海洋防污剂的用途。
• A method to control termites
  申请人：ROHM AND HAAS COMPANY

  公开号：EP1112688A1

  公开（公告）日：2001-07-04

  The present invention relates to a method for controlling termites by treating the termites or the locus wherein the termites live, with a 5-carboxanilido-bis-trifluoromethyl-thiazole fungicide. This invention also relates to a method for controlling the damage caused by termites and to termite damage resistant articles.

  本发明涉及一种用 5-甲酰苯胺基-双三氟甲基噻唑杀菌剂处理白蚁或白蚁生活的地 点，从而控制白蚁的方法。本发明还涉及一种控制白蚁危害的方法和抗白蚁危害的物品。