N-{4-[3,3-Dimethyl-7-oxo-9-(2-oxo-1,2-dihydro-pyridin-3-yl)-2,3,7,8-tetrahydro-furo[3,2-g]quinolin-6-yl]-phenyl}-methanesulfonamide | 1243243-10-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: N-{4-[3,3-Dimethyl-7-oxo-9-(2-oxo-1,2-dihydro-pyridin-3-yl)-2,3,7,8-tetrahydro-furo[3,2-g]quinolin-6-yl]-phenyl}-methanesulfonamide
• 英文别名: N-[4-[3,3-dimethyl-7-oxo-9-(2-oxo-1H-pyridin-3-yl)-2,8-dihydrofuro[3,2-g]quinolin-6-yl]phenyl]methanesulfonamide
• CAS: 1243243-10-8
• 化学式: C₂₅H₂₃N₃O₅S
• 分子量: 477.541
• InChiKey: ZLMVARWKBNPZGC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  34
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  122
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• HETEROCYCLIC ANTIVIRAL COMPOUNDS
  申请人：Abbot Sarah C.

  公开号：US20100226879A1

  公开（公告）日：2010-09-09

  Compounds having the formula A-R wherein A is a hetereoaryl and R is Ia, Ib or Ic and wherein A, R, R 1 , R 2a , R 2b , R 2c , R 3a , R 3b , R 4 , R 5 , R 6 , R a , R b , R c , R d , X, X 1 , X 2 and n are as are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication. R is

  化合物的化学式为A-R，其中A是杂环芳基，R是Ia，Ib或Ic，A，R，R1，R2a，R2b，R2c，R3a，R3b，R4，R5，R6，Ra，Rb，Rc，Rd，X，X1，X2和n的定义如本文所述，是丙型肝炎病毒NS5b聚合酶抑制剂。还公开了用于治疗HCV感染和抑制HCV复制的组合物和方法。R是...（未提供完整信息）
• US8168792B2
  申请人：——

  公开号：US8168792B2

  公开（公告）日：2012-05-01
• [EN] HETEROCYCLIC ANTIVIRAL COMPOUNDS<br/>[FR] COMPOSÉS ANTIVIRAUX HÉTÉROCYCLIQUES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2010100178A1

  公开（公告）日：2010-09-10

  Compounds having the formula A-R wherein A is a hetereoaryl and R is Ia, Ib or Ic and wherein A, R, R1, R2a, R2b, R2c, R3a, R3b, R4, R5, R6, Ra, Rb, Rc, Rd, X, X1, X2 and n are as are as defined herein are Hepatitis C virus NS5b polymerase inhibitors. Also disclosed are compositions and methods for treating an HCV infection and inhibiting HCV replication.