7-Nitro-[1,4]benzoxathiino[3,2-b]pyridine 10,10-dioxide | 72719-68-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 7-Nitro-[1,4]benzoxathiino[3,2-b]pyridine 10,10-dioxide
• CAS: 72719-68-7
• 化学式: C₁₁H₆N₂O₅S
• 分子量: 278.245
• InChiKey: MQKSOLBMEAZMIV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  19
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  111
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  7-Nitro-[1,4]benzoxathiino[3,2-b]pyridine 10,10-dioxide 在 palladium on activated charcoal 氢气 作用下， 以 溶剂黄146 为溶剂， 以46%的产率得到N-(10,10-dioxo-[1,4]benzoxathiino[3,2-b]pyridin-7-yl)hydroxylamine
  参考文献：
  名称：

  Central nervous system activity of 7-substituted 1-azaphenoxathiin analogs and their oxidation products

  摘要：

  A number of 7-substituted 1-azaphenoxathiins and their sulfone oxidation products have been synthesized and screened for central nervous system activity. Some of the compounds have antidepressant activity, with the most active, 7-(trifluoromethyl)-1-azaphenoxathiin 10,10-dioxide (8), having similar potency to imipramine.

  DOI：

  10.1021/jm00177a028
• 作为产物：
  描述：

  7-nitro-benzo[5,6][1,4]oxathiino[3,2-b]pyridine 在 双氧水 作用下， 以 溶剂黄146 为溶剂， 反应 0.25h， 以69%的产率得到7-Nitro-[1,4]benzoxathiino[3,2-b]pyridine 10,10-dioxide
  参考文献：
  名称：

  Central nervous system activity of 7-substituted 1-azaphenoxathiin analogs and their oxidation products

  摘要：

  A number of 7-substituted 1-azaphenoxathiins and their sulfone oxidation products have been synthesized and screened for central nervous system activity. Some of the compounds have antidepressant activity, with the most active, 7-(trifluoromethyl)-1-azaphenoxathiin 10,10-dioxide (8), having similar potency to imipramine.

  DOI：

  10.1021/jm00177a028

文献信息

• MEHTA M. U.; MARTIN G. E.; SMITH K., J. HETEROCYCL. CHEM., 24,(1987) N 1, 235-237
  作者：MEHTA M. U.、 MARTIN G. E.、 SMITH K.

  DOI：——

  日期：——
• Central nervous system activity of 7-substituted 1-azaphenoxathiin analogs and their oxidation products
  作者：Arthur J. Elliott、Norman Eisenstein、Louis C. Iorio

  DOI：10.1021/jm00177a028

  日期：1980.3

  A number of 7-substituted 1-azaphenoxathiins and their sulfone oxidation products have been synthesized and screened for central nervous system activity. Some of the compounds have antidepressant activity, with the most active, 7-(trifluoromethyl)-1-azaphenoxathiin 10,10-dioxide (8), having similar potency to imipramine.