[3-(t-butyloxycarbonylamino)-1-propylamino]acetate | 158073-49-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [3-(t-butyloxycarbonylamino)-1-propylamino]acetate
• 英文别名: (3-tert-butoxycarbonylaminopropyl)glycine；2-[3-[(2-methylpropan-2-yl)oxycarbonylamino]propylamino]acetic acid
• CAS: 158073-49-5
• 化学式: C₁₀H₂₀N₂O₄
• 分子量: 232.28
• InChiKey: HXMZGCLIRQXHSQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  16
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  87.7
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [3-(t-butyloxycarbonylamino)-1-propylamino]acetate 、 溴乙酰溴 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 以71%的产率得到N-(p-methoxybenzylcarboxymethyl)-N-[3-(t-butyloxy-carbonylamino)-1-propyl]bromoacetamide
  参考文献：
  名称：

  Cephalosporin derviatives

  摘要：

  以通式##STR1##表示的新型头孢菌素衍生物，其中酰基取代物是通式##STR2##中的一个基团，其中Ar是一个亲脂性可选择取代的苯基、萘基或吡啶基；R.sup.1代表杂环氨基酸残基或被羧基和通式--NR.sup.9 R.sup.10或##STR3##中的一个基团取代的C.sub.2 -C.sub.10烷基基团，其中R.sup.9和R.sup.10各自独立地是氢或C.sub.1 -C.sub.6烷基，所述C.sub.2 -C.sub.10烷基基团可选择地被一个或多个氮原子或羰基所中断，且R.sup.2和R.sup.3各自独立地是氢、烷基或氨基烷基，是革兰氏阳性抗菌剂，特别适用于治疗由耐甲氧苄青霉素金黄色葡萄球菌（也称为MRSA或耐甲氧苄青霉素金黄色葡萄球菌）引起的疾病。

  公开号：

  US05620969A1
• 作为产物：
  描述：

  叔-丁基(3-(苯甲基氨基)丙基)氨基甲酯 在 palladium on activated charcoal 氢气 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 25.0 ℃ 、413.69 kPa 条件下， 反应 7.5h， 生成 [3-(t-butyloxycarbonylamino)-1-propylamino]acetate
  参考文献：
  名称：

  Building Units for N-Backbone Cyclic Peptides. 3. Synthesis of Protected N^α-(ω-Aminoalkyl)amino Acids and N^α-(ω-Carboxyalkyl)amino Acids

  摘要：

  An improved synthesis of a family of amino acids that contain omega-aminoalkyl groups and of a new family containing omega-carboxyalkyl groups linked to the alpha-amine is described. The synthesis was performed by alkylation of suitably monoprotected alkylenediamines and protected omega-amino acids with triflates of alpha-hydroxy acid esters. The reaction proceeded with inversion of configuration yielding optically pure products. The N-alpha-(omega-aminoalkyl)amino acids and N-alpha-(omega-carboxyalkyl)amino acids were orthogonally protected to allow their incorporation into peptides by solid-phase peptide synthesis (SPPS) methodology.

  DOI：

  10.1021/jo961580e

文献信息

• Building units for N-backbone cyclic peptides. Part 4.1 Synthesis of protected Nα-functionalized alkyl amino acids by reductive alkylation of natural amino acids
  作者：Gal Bitan、Dan Muller、Ron Kasher、Evgenia V. Gluhov、Chaim Gilon

  DOI：10.1039/a608389g

  日期：——

  A new method for the synthesis of protected Nα-(ω-Y-alkyl) amino acids (Y is a thio, amino or carboxy group) and related compounds by reductive alkylation of natural amino acids is reported. These new amino acids serve as building units for the synthesis of backbone-cyclic peptides. They are orthogonally protected at the α-amino position by butoxycarbonyl (Boc) or 9-fluorenylmethoxycarbonyl (Fmoc), using trimethylsilyl temporary protection, to allow for their incorporation into peptides by solid phase peptide synthesis.

  报道了一种通过天然氨基酸的还原烷基化合成保护的Nα-(γ-Y-烷基)氨基酸(Y为硫、氨基或羧基基团)及相关化合物的新方法。这些新型氨基酸作为合成骨架环肽的构建单元，在α-氨基位置通过叔丁氧羰基(Boc)或9-芴甲氧羰基(Fmoc)进行正交保护，并使用三甲基硅烷临时保护，以便通过固相肽合成法将其并入肽链中。
• Substituted amino compounds, their preparation and their use as
  申请人：Hoechst Aktiengesellschaft

  公开号：US05681838A1

  公开（公告）日：1997-10-28

  The present invention relates to novel substituted amino compounds of the formula I: R.sup.1 -(A).sub.a -(B).sub.b -(D).sub.c -(CH.sub.2).sub.m -N(R.sup.2)-(CH.sub.2).sub.n -R.sup.3 as defined in the present application, and to a process for preparing such compounds. The invention also includes pharmaceutical compositions containing the present compounds, and the preparation of such compositions. The invention also relates to the use of the present compounds as inhibitors of blood-platelet aggregation, formation of metastases by carcinoma cells, and the binding of osteoclasts to bone surfaces, in the treatment of hosts in need thereof.

  本发明涉及以下式的新型取代氨基化合物：R.sup.1 -(A).sub.a -(B).sub.b -(D).sub.c -(CH.sub.2).sub.m -N(R.sup.2)-(CH.sub.2).sub.n -R.sup.3，如本申请中所定义，并涉及制备这种化合物的方法。本发明还包括含有本化合物的药物组合物，以及制备这种组合物。本发明还涉及将本化合物用作抑制血小板聚集、癌细胞形成转移灶以及破骨细胞与骨表面结合的药物，在治疗需要的宿主中的用途。
• Peptoid affinity ligands
  申请人：Menegatti Stefano

  公开号：US10065988B2

  公开（公告）日：2018-09-04

  Compounds of Formulas I: and shorter variants thereof are described, along with solid supports having such compounds coupled thereto, and the use thereof as affinity ligands for antibodies.

  式 I 的化合物 及其更短的变体，以及具有这种化合物的固体支撑物，并将其用作抗体的亲和配体。
• Building units for N-backbone cyclic peptides. 1. Synthesis of protected N-(.omega.-aminoalkylene)amino acids and their incorporation into dipeptide units
  作者：Gerardo Byk、Chaim Gilon

  DOI：10.1021/jo00047a022

  日期：1992.10

  A variety of new amino acids which contain an omega-aminoalkylene group on the N(alpha)-amino nitrogen were synthesized by alkylation of alkylenediamines with alpha-halogeno acids. The reaction proceeds with inversion of configuration; thus, optically pure products were obtained when optically active a-halogeno acids were used. The N-(omega-aminoalkylene)amino acids were protected by orthogonal protecting groups to allow their incorporation into dipeptides by the "solution" techniques and into peptides by the solid-phase peptide synthesis (SPPS) methodology. A series of dipeptide analogs of Phe-Gly, Leu-Gly, Trp-Gly, Phe-Leu, and Phe-Ala in which the nitrogen of the peptide bond is alkylated by omega-aminoalkylene chains with various lengths were prepared. These new protected N-(omega-aminoalkylene)amino acids and their derived dipeptide units may be used as building blocks for conformationally constrained N-backbone cyclic peptides.
• SUBSTITUIERTE AMINOVERBINDUNGEN, IHRE HERSTELLUNG UND IHRE VERWENDUNG ALS HEMMSTOFFE DER THROMBOZYTENAGGREGATION
  申请人：CASSELLA Aktiengesellschaft

  公开号：EP0680468A1

  公开（公告）日：1995-11-08