2-imidazolylcyclohexanol

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-imidazolylcyclohexanol
• 英文别名: 2-(imidazol-1-yl)cyclohexanol；2-(1H-imidazol-1-yl)cyclohexan-1-ol；2-imidazol-1-ylcyclohexan-1-ol
• 化学式: C₉H₁₄N₂O
• 分子量: 166.223
• InChiKey: HELVEFCDBSXYQT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  38
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-imidazolylcyclohexanol 在 immobilized lipase B from Candida antarctica 作用下， 以 氯仿 、 乙腈 为溶剂， 生成 1-(2-acetoxycyclohex-1-yl)-3-methyl-1H-imidazol-3-ium iodide
  参考文献：
  名称：

  Enhanced Hydrogen-Transfer Catalytic Activity of Iridium N-Heterocyclic Carbenes by Covalent Attachment on Carbon Nanotubes

  摘要：

  Oxidized multiwall carbon nanotubes (CNT) were covalently modified with appropriate hydroxyl-ending imidazolium salts using their carboxylic acid groups. Characterization of the imidazolium-modified samples through typical solid characterization techniques, such as TGA or XPS, allows for the determination of 16 wt % in CNT-1 and 31 wt % in CNT-2 as the amount of the imidazolic fragments in the carbon nanotubes. The imidazolium-functionalized materials were used to prepare nanohybrid materials containing iridium N-heterocyclic carbene (NHC)-type organometallic complexes with efficiencies as high as 95%. The nanotube-supported iridium-NHC materials were active in the heterogeneous iridium-catalyzed hydrogen-transfer reduction of cyclohexanone to cyclohexanol with 2-propanol/KOH as hydrogen source. The iridium hybrid materials are more efficient than related homogeneous catalysts based on acetoxy-functionalized Ir-NHC complexes with initial TOFs up to 5550 h(-1). A good recyclability of the catalysts, without any loss of activity, and stability in air was observed.

  DOI：

  10.1021/cs4000798
• 作为产物：
  描述：

  咪唑 、 氧化环己烯 生成 2-imidazolylcyclohexanol
  参考文献：
  名称：

  MURABAYASHI, AKIRA;MAKISUMI, YASUO, HETEROCYCLES, 31,(1990) N, C. 537-548

  摘要：

  DOI：

文献信息

• Cycloalkane Derivatives
  申请人：Daiichi Sankyo Company, Limited

  公开号：US20140045862A1

  公开（公告）日：2014-02-13

  Disclosed herein are therapeutic agents and/or preventive agents for pain or therapeutic agents and/or preventive agents for a sodium channel associated disease. The present invention provides compounds represented by the following formula (I) or pharmacologically acceptable salts thereof:

  本文揭示了用于疼痛的治疗剂和/或预防剂，或者用于钠通道相关疾病的治疗剂和/或预防剂。本发明提供以下式（I）所代表的化合物或其药理学上可接受的盐：
• [EN] ANTITHROMBOTIC DIAMINES<br/>[FR] DIAMINES ANTITHROMBOTIQUES
  申请人：ELI LILLY AND COMPANY

  公开号：WO1997025033A1

  公开（公告）日：1997-07-17

  (EN) This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula (I) as defined herein. It also provides novel compounds of formula (I), processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula (I).(FR) La présente invention concerne l'utilisation, comme inhibiteurs de thrombine, inhibiteurs de coagulation et agents destinés aux désordres de la thromboembolie, de diamines de formule I telle qu'elle est définie dans la description. L'invention concerne aussi des composés nouveaux de formule I, des procédés et des produits intermédiaires pour leur préparation, et des formulations pharmaceutiques comprenant les composés nouveaux de formule I.

  该应用涉及使用公式（I）所定义的二胺作为凝血酶抑制剂、凝血抑制剂和血栓栓塞疾病药物的用途。它还提供了公式（I）的新化合物、其制备过程和中间体，以及包含公式（I）的新药物配方。
• MAKIKADO, TOKUO;MURAXAYASI, AKIRA;XATA, TAKAYUKI;ISIGURO, TAKEHO
  作者：MAKIKADO, TOKUO、MURAXAYASI, AKIRA、XATA, TAKAYUKI、ISIGURO, TAKEHO

  DOI：——

  日期：——
• EP0863755A4
  申请人：——

  公开号：EP0863755A4

  公开（公告）日：1999-01-20
• ANTITHROMBOTIC DIAMINES
  申请人：ELI LILLY AND COMPANY

  公开号：EP0863755A1

  公开（公告）日：1998-09-16