2'-ethylsulfanylacetophenone | 70201-55-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2'-ethylsulfanylacetophenone
• 英文别名: 1-[2-(Ethylsulfanyl)phenyl]ethan-1-one；1-(2-ethylsulfanylphenyl)ethanone
• CAS: 70201-55-7
• 化学式: C₁₀H₁₂OS
• mdl: MFCD11136965
• 分子量: 180.271
• InChiKey: DRZLTLOQRZJNCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2'-ethylsulfanylacetophenone 在 m-chloroperoxybenzoic acid 作用下， 以 氯仿 为溶剂， 反应 4.0h， 以3.5 g的产率得到2'-ethylsulfonylacetophenone
  参考文献：
  名称：

  FUSED HETEROCYCLIC COMPOUND

  摘要：

  公开号：

  EP2862853B1
• 作为产物：
  描述：

  2'-溴苯乙酮 、 乙硫醇 在 potassium tert-butylate 作用下， 以 氨 为溶剂， 反应 1.0h， 以90%的产率得到2'-ethylsulfanylacetophenone
  参考文献：
  名称：

  爱丽宫德反应小号RN 1 partie 10：行动去sulfanions河畔莱halogenures D'aryle fonctionnalises。苯并噻吩和噻吩并吡啶类合成药物

  摘要：

  官能化的芳族卤化物的Ar 1 XY（AR 1 = C 6 H ^ 4，Y = OCH 3，CONH 2，CN，COCH 3，CHO，COC 6 H ^ 5）经历小号RN 1个反应用硫阴离子- SR，无论是简单的（R ＝ C 2 H 5，CH 2 C 6 H 5）或官能化的（R ＝（CH 2）2 OH，（CH 2）2 CO 2 Et，CH 2 CO 2 Et）。产品Ar1个YS -从阴离子自由基的Ar的碎片形成1 YSR -都与芳基部分Ar的氧化还原电位1 Y和与接合SR的能量。在杂环系列（Ar 2 =吡啶，Ar 3 =喹啉）中，出现了相似的关系，但带有吸电子基团的吡啶底物发生竞争性S N（Ar）反应。据报道，通过S RN 1反应可直接合成苯并噻吩，并基于S N（Ar）反应可改进噻吩并吡啶的合成。

  DOI：

  10.1016/s0040-4020(01)88635-x

文献信息

• Fused heterocyclic compound
  申请人：Sumitomo Chemical Company, Limited

  公开号：US09271500B2

  公开（公告）日：2016-03-01

  The fused heterocyclic compound represented by formula (1), or an N-oxide thereof, has excellent effectiveness in pest control. In the formula G1 represents a nitrogen atom, etc.; G2 represents a nitrogen atom, etc.; A1 represents a nitrogen atom, etc.; A2 represents a nitrogen atom, etc.; A3 represents a nitrogen atom, etc.; A4 represents a nitrogen atom, etc.; A5 represents a nitrogen atom, etc.; R1 represents a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; R2, R3 and R4 are the same or different, and represent a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; R5 and R6 are the same or different, and represent a C1-C6 chain hydrocarbon group, etc., optionally having one or more atoms or groups selected from group X; and n represents 0, 1, 2.

  公式（1）所代表的融合杂环化合物，或其N-氧化物，在害虫控制方面具有出色的效果。在公式中，G1代表氮原子等；G2代表氮原子等；A1代表氮原子等；A2代表氮原子等；A3代表氮原子等；A4代表氮原子等；A5代表氮原子等；R1代表C1-C6链烃基等，可选地具有来自X组的一个或多个原子或基团；R2、R3和R4相同或不同，代表C1-C6链烃基等，可选地具有来自X组的一个或多个原子或基团；R5和R6相同或不同，代表C1-C6链烃基等，可选地具有来自X组的一个或多个原子或基团；n代表0、1或2。
• PYRAZOLONE DERIVATIVES AS NITROXYL DONORS
  申请人：Cardioxyl Pharmaceuticals, Inc.

  公开号：US20150344437A1

  公开（公告）日：2015-12-03

  The disclosed subject matter provides pyrazolone derivative compounds, pharmaceutical compositions comprising such compounds, kits comprising such compounds, and methods of using such compounds or pharmaceutical compositions. In particular, the disclosed subject matter provides methods of using such compounds or pharmaceutical compositions for treating heart failure.

  所披露的主题提供了吡唑酮衍生物化合物，包含这些化合物的药物组合物，包含这些化合物的工具箱，以及使用这些化合物或药物组合物的方法。具体而言，所披露的主题提供了使用这些化合物或药物组合物治疗心力衰竭的方法。
• Synthesis and reactivity of 2-(ethylthio) phenylcopper: A stable organocopper compound carrying an intramolecular sulfane ligand
  作者：Shinji Toyota、Michinori Ōki

  DOI：10.1016/s0022-328x(96)06496-0

  日期：1997.4

  An unusually stable organocopper compound carrying an intramolecular sulfane ligand, 2-(ethylthio)phenylcopper, was synthesized via the reaction of the corresponding organolithium with a copper(I) halide (CuX). This compound was obtained in two forms: one is a salt - free compound which is insoluble in ordinary solvents, the other is a soluble complex of [2-(ethylthio)phenylcopper](2) . CuX composition. These compounds were either hydrolyzed or underwent a coupling reaction to produce a biphenyl when heated. While these organocoppers are less reactive towards various electrophiles than other known arylcoppers, the soluble complex gives ketones with acyl halides in low yields. The properties as well as the reactivities of the stable organocopper compounds are reported.
• Synthesis and evaluation of 1-(benzo[b]thiophen-2-yl)ethanone analogues as novel anti-osteoporosis agents acting on BMP-2 promotor
  作者：Zong-ying Liu、Xiao-bo He、Zhao-yong Yang、Hua-yi Shao、Xue Li、Hui-fang Guo、Yue-qin Zhang、Shu-yi Si、Zhuo-rong Li

  DOI：10.1016/j.bmcl.2009.05.118

  日期：2009.8

  A novel series of 1-(benzo[b]thiophen-2-yl)ethanone analogues were prepared and evaluated for enhancing BMP-2 expression. Compounds 1-5, 7, 8, 12, 13 and 16, with upregulation rate values of 35.6%, 27.9%, 39.8%, 32.0%, 37.1%, 30.2%, 28.0%, 33.5%, 22.8% and 27.3% in vitro, respectively, at a concentration of 4 mu M, exhibited potent effect for enhancing BMP-2 expression. We also found that compounds 1 and 12 produced a dose-dependent increase on bone histology and histomorphometry, and effectively reduced bone defects induced by ovariectomy in an ovariectomized rat model (OVX). (C) 2009 Elsevier Ltd. All rights reserved.
• BEUGELMANS, R.;BOIS-CHOUSSY, M.;BOUDET, B., TETRAHEDRON, 1983, 39, N 24, 4153-4161
  作者：BEUGELMANS, R.、BOIS-CHOUSSY, M.、BOUDET, B.

  DOI：——

  日期：——