3-hydroxy-2-oxo-1-oxaspiro[4.5]decane | 274913-93-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 内酯类
• 英文名称: 3-hydroxy-2-oxo-1-oxaspiro[4.5]decane
• 英文别名: 3-Hydroxy-1-oxaspiro[4.5]decan-2-one
• CAS: 274913-93-8
• 化学式: C₉H₁₄O₃
• 分子量: 170.208
• InChiKey: RBFSTRXQTCMDLO-UHFFFAOYSA-N

物化性质

• 沸点：
  328.4±17.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  丙烯酸甲酯（MA） 、 环己醇 在 cobalt(II) acetate N-羟基邻苯二甲酰亚胺 、 cobalt(III) acetylacetonate 、 氧气 作用下， 以 乙腈 为溶剂， 反应 3.0h， 以83%的产率得到3-hydroxy-2-oxo-1-oxaspiro[4.5]decane
  参考文献：
  名称：

  Catalytic α-hydroxy carbon radical generation and addition. Synthesis of α-hydroxy-γ-lactones from alcohols, α,β-unsaturated esters and dioxygen

  摘要：

  开发了一种从醇生成α-羟基碳自由基的催化方法，并构建了一种方便且在合成上有用的制备α-羟基-γ-内酯的途径。

  DOI：

  10.1039/b000707m

文献信息

• Unsaturated carboxylic acid hemicacetal ester, polymeric compound and photoresist resin composition
  申请人：Koyama Hiroshi

  公开号：US20060160247A1

  公开（公告）日：2006-07-20

  A polymeric compound having a repeated unit corresponding to an unsaturated carboxylic acid hemiacetal ester represented by the following formula (1); wherein R a is a hydrogen atom, a halogen atom, an alkyl group of carbon number 1 to 6 or a haloalkyl group of carbon number 1 to 6, R b is a hydrocarbon group having a hydrogen atom at a first poison, R c is a hydrogen atom or a hydrocarbon group and R d is an organic group having a cyclic skeleton. This polymeric compound, further, may have a repeated unit corresponding to at least one monomer selected from a monomer having a lactone skeleton, a monomer having a cyclic ketone skeleton, a monomer having an acid anhydride group and a monomer having an imide group [except for a repeated unit corresponding to the said unsaturated carboxylic acid hemiacetal ester] and/or a repeated unit corresponding to at least one monomer selected from a monomer having a hydroxyl group and others. This polymeric compound shows superior acid-eliminating function in case of using as photoresist.

  一种聚合物化合物，其重复单元对应于由以下式（1）表示的不饱和羧酸半缩醛酯： 其中，R为氢原子，卤素原子，碳数为1到6的烷基或碳数为1到6的卤代烷基，Rb为在第一位置具有氢原子的碳氢基，Rc为氢原子或碳氢基，而Rd为具有环状骨架的有机基团。此聚合物化合物还可以具有对应于至少一种单体的重复单元，所述单体具有内酯骨架、环状酮骨架、酸酐基或亚酰胺基[除了对应于所述不饱和羧酸半缩醛酯的重复单元]和/或对应于至少一种具有羟基的单体的重复单元和其他单体。该聚合物化合物在用作光刻胶时表现出优越的酸消除功能。
• Process for the preparation of organic compounds with imide catalysts
  申请人：Daicel Chemical Industries, Ltd.

  公开号：US07183423B1

  公开（公告）日：2007-02-27

  (A) A compound capable of forming a stable radical and selected from (A1) oxygen-atom-containing compounds each having a carbon-hydrogen bond at the adjacent position to an oxygen atom, (A2) carbonyl-group-containing compounds, and (A3) compounds each having a hydrocarbon group with a methine carbon atom is allowed to react with (B) a radical scavenging compound selected from, for example, (B1) unsaturated compounds, and (B2) compounds each having a hydrocarbon group with a methine carbon atom, in the presence of molecular oxygen by catalysis of, for example, an imide compound shown by the following formula (1): wherein each of R1 and R2 is a hydrogen atom or the like, where R1 and R2 may be combined to form a double bond, or an aromatic or non-aromatic ring; X is an oxygen atom or a hydroxyl group, to yield a product of an addition or substitution reaction of the compound (A) and the compound (B) or its oxidized product. The process can efficiently produce a variety of organic compounds by an addition or substitution reaction using molecular oxygen under mild conditions.

  (A) 从以下化合物中选择一个能够形成稳定自由基的化合物：(A1) 含有氧原子的化合物，其邻近氧原子处有碳氢键，(A2) 含有羰基的化合物，和 (A3) 含有甲烷碳原子的碳氢基团化合物。将其与 (B) 自由基清除化合物反应，该化合物可从以下化合物中选择：(B1) 不饱和化合物，和 (B2) 含有甲烷碳原子的碳氢基团化合物，在分子氧的存在下通过以下式(1)所示的亚酰化合物的催化作用下进行反应：其中R1和R2分别为氢原子或类似物，其中R1和R2可以结合形成双键，或芳香或非芳香环; X为氧原子或羟基，从而生成化合物(A)和化合物(B)或其氧化产物的加成或取代反应产物。该过程可以在温和条件下使用分子氧进行加成或取代反应，高效地产生各种有机化合物。
• PROCESS FOR THE PREPARATION OF ORGANIC COMPOUNDS WITH IMIDE CATALYSTS
  申请人：Daicel Chemical Industries, Ltd.

  公开号：EP1055654B1

  公开（公告）日：2008-02-20
• US7183423B1
  申请人：——

  公开号：US7183423B1

  公开（公告）日：2007-02-27
• Catalytic α-hydroxy carbon radical generation and addition. Synthesis of α-hydroxy-γ-lactones from alcohols, α,β-unsaturated esters and dioxygen
  作者：Takahiro Iwahama、Satoshi Sakaguchi、Yasutaka Ishii

  DOI：10.1039/b000707m

  日期：——

  A catalytic method for α-hydroxy carbon radical generation from alcohols has been developed and a convenient and synthetically useful approach to α-hydroxy-γ-lactones constructed.

  开发了一种从醇生成α-羟基碳自由基的催化方法，并构建了一种方便且在合成上有用的制备α-羟基-γ-内酯的途径。