p-Nitrophenyl α-D-arabinopyranoside | 72732-53-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: p-Nitrophenyl α-D-arabinopyranoside
• 英文别名: (2R,3S,4R,5R)-2-(4-nitrophenoxy)oxane-3,4,5-triol
• CAS: 72732-53-7
• 化学式: C₁₁H₁₃NO₇
• 分子量: 271.227
• InChiKey: MLJYKRYCCUGBBV-CHWFTXMASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  p-Nitrophenyl α-D-arabinopyranoside 在 甲醇 、 钯 作用下， 生成 (4-amino-phenyl)-α-D-arabinopyranoside
  参考文献：
  名称：

  Feier; Westphal, Chemische Berichte, 1956, vol. 89, p. 589,593

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 sodium methylate 作用下， 生成 p-Nitrophenyl α-D-arabinopyranoside
  参考文献：
  名称：

  Feier; Westphal, Chemische Berichte, 1956, vol. 89, p. 589,593

  摘要：

  DOI：

文献信息

• Direct Synthesis of <i>para</i>-Nitrophenyl Glycosides from Reducing Sugars in Water
  作者：Xin Qiu、Antony J. Fairbanks

  DOI：10.1021/acs.orglett.0c00728

  日期：2020.3.20

  be directly converted into the corresponding para-nitrophenyl (pNP) glycosides using 2-chloro-1,3-dimethylimidazolinium chloride (DMC), para-nitrophenol, and a suitable base in aqueous solution. The reaction is stereoselective for sugars with either a hydroxyl or an acetamido group at position 2, yielding the 1,2-trans pNP glycosides. A judicious choice of base allows extension to di- and oligosaccharide

  可以使用2-氯-1,3-二甲基咪唑啉鎓氯化物（DMC），对硝基苯酚和合适的碱在水溶液中将还原糖直接转化为相应的对硝基苯基（p NP）糖苷。对于在2位具有羟基或乙酰氨基的糖，该反应是立体选择性的，产生1，2-反式p NP糖苷。碱的明智选择允许扩展至二糖和寡糖底物，包括从天然来源分离的复杂的N-聚糖低聚糖，而无需任何保护基团的操作
• TRICLOSAN DERIVATIVES AND USES THEREOF
  申请人：Oxoid Limited

  公开号：US20140178923A1

  公开（公告）日：2014-06-26

  A selective agent comprising a triclosan derivative for use in selective inhibition of non-target cells in a mixed population of target and non-target cells. Preferably the triclosan derivative is a glycoside derivative, more preferably a pyranoside derivative. Suitably a selective medium comprising said selective agent and methods of culturing cells using the selective agent are provided.

  包含三氯生衍生物的选择性抑制剂，用于在目标细胞和非目标细胞混合群体中选择性抑制非目标细胞。最好的三氯生衍生物是糖苷衍生物，更好的是吡喃糖苷衍生物。提供了包含所述选择性抑制剂的选择性培养基和使用该选择性抑制剂培养细胞的方法。
• Engineered enzymes and their use for synthesis of thioglycosides
  申请人：Withers G Stephen

  公开号：US20060035342A1

  公开（公告）日：2006-02-16

  Mutant glycosidases in which the amino acid in the active site that serves as the acid, base or acid/base-catalyst is converted from a carboxylic acid to some other amino acid (for example to a simple alkyl, as in alanine or glycine) can catalyze the reaction of a thiosugar acceptor and an activated donor to form a thioglycoside. The “thioglycoligases” represent a novel class of mutant enzymes, and represent a first aspect of the invention. Thioglycoligases can be used in accordance with the method of the invention to couple a thiosugar acceptor and an activated donor to form a thioglycoside. By selection of the donor and acceptor species, as well as the specific enzyme employed, thioglycosides of different structure and stereochemistry can be obtained.

  突变的糖苷酶中，活性位点中作为酸、碱或酸碱催化剂的氨基酸从羧酸转变为其他氨基酸（例如转变为简单的烷基，如丙氨酸或甘氨酸），可以催化硫代糖受体和活化供体的反应，形成硫代糖苷。 "硫代糖聚合酶"代表一类新型突变酶，并代表本发明的第一个方面。可以根据本发明的方法使用硫代糖聚合酶将硫代糖受体和活化供体偶联形成硫代糖苷。通过选择供体和受体物种以及特定的酶，可以获得不同结构和立体化学的硫代糖苷。
• Engineered Enzymes and Their Use for Synthesis of Thioglycosides
  申请人：Withers G. Stephen

  公开号：US20070004010A1

  公开（公告）日：2007-01-04

  Mutant glycosidases in which the amino acid in the active site that serves as the acid, base or acid/base-catalyst is converted from a carboxylic acid to some other amino acid (for example to a simple alkyl, as in alanine or glycine) can catalyze the reaction of a thiosugar acceptor and an activated donor to form a thioglycoside. The “thioglycoligases” represent a novel class of mutant enzymes, and represent a first aspect of the invention. Thioglycoligases can be used in accordance with the method of the invention to couple a thiosugar acceptor and an activated donor to form a thioglycoside. By selection of the donor and acceptor species, as well as the specific enzyme employed, thioglycosides of different structure and stereochemistry can be obtained.

  突变的糖苷酶中，活性位点中作为酸、碱或酸碱催化剂的氨基酸从羧酸转变为其他氨基酸（例如转变为简单的烷基，如丙氨酸或甘氨酸），可以催化硫代糖受体和活化供体的反应形成硫代糖苷。这些“硫代糖合酶”代表了突变酶的一类新型酶，也代表了本发明的第一个方面。可以根据本方法使用硫代糖受体和活化供体耦合形成硫代糖苷。通过选择供体和受体物种以及具体的酶，可以获得不同结构和立体化学的硫代糖苷。
• NOVEL GLYCOSYL HYDROLASE WITH BETA-XYLOSIDASE AND BETA-GLUCOSIDASE ACTIVITIES AND USES THEREOF
  申请人：Zhu Ping

  公开号：US20130130330A1

  公开（公告）日：2013-05-23

  A novel glycosyl hydrolase with activities of beta-xylosidase and beta-glucosidase is provided. Said glycosyl hydrolase can convert 7-xylosyltaxane compounds to 7-hydroxyltaxane compounds.

  提供了一种新型的糖基水解酶，具有β-木糖苷酶和β-葡萄糖苷酶的活性。该糖基水解酶可以将7-木糖基紫杉烷类化合物转化为7-羟基紫杉烷类化合物。