7-(1,2,3,4,4a,5,7,7a-Octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid;hydron;chloride | 1185253-35-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 7-(1,2,3,4,4a,5,7,7a-Octahydropyrrolo[3,4-b]pyridin-6-yl)-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid;hydron;chloride
• CAS: 1185253-35-3
• 化学式: C21H25ClFN3O4
• 分子量: 437.9
• InChiKey: IDIIJJHBXUESQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.79
• 重原子数：
  30
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  82.1
• 氢给体数：
  3
• 氢受体数：
  8

文献信息

• Compositions for treating neurological disorders
  申请人：PHARNEXT

  公开号：US10434109B2

  公开（公告）日：2019-10-08

  The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.

  本发明涉及治疗与谷氨酸兴奋毒性和淀粉样蛋白β毒性相关的神经系统疾病的组合物和方法。更具体地说，本发明涉及多发性硬化症、阿尔茨海默病、阿尔茨海默病相关疾病、肌萎缩侧索硬化症、帕金森病、亨廷顿病、神经性疼痛、酒精性神经病、酗酒或戒酒或脊髓损伤的新型组合疗法。
• NEW COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
  申请人：Pharnext

  公开号：EP2680836B1

  公开（公告）日：2018-06-13
• EP3038614A1
  申请人：——

  公开号：EP3038614A1

  公开（公告）日：2016-07-06
• COMPOSITION COMPRISING TORASEMIDE AND BACLOFEN FOR TREATING NEUROLOGICAL DISORDERS
  申请人：Pharnext

  公开号：EP3038614B1

  公开（公告）日：2019-04-03
• COMPOSITIONS FOR TREATING NEUROLOGICAL DISORDERS
  申请人：PHARNEXT

  公开号：US20140038927A1

  公开（公告）日：2014-02-06

  The present invention relates to compositions and methods for the treatment of neurological disorders related to glutamate excitotoxicity and Amyloid β toxicity. More specifically, the present invention relates to novel combinatorial therapies of Multiple Sclerosis, Alzheimer's disease, Alzheimer's disease related disorders, Amyotrophic Lateral Sclerosis, Parkinson's disease, Huntington's disease, neuropathic pain, alcoholic neuropathy, alcoholism or alcohol withdrawal, or spinal cord injury.