[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-quinolin-3-yl-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: [1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-quinolin-3-yl-amine
• 英文别名: 1-(4-fluorophenyl)-N-(3-quinolyl)methanimine；1-(4-fluorophenyl)-N-quinolin-3-ylmethanimine
• 化学式: C₁₆H₁₁FN₂
• 分子量: 250.275
• InChiKey: KUXIARCVPKLXPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  25.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  [1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-quinolin-3-yl-amine 在 sodium tetrahydroborate 作用下， 以 四氢呋喃 为溶剂， 反应 4.0h， 以57%的产率得到(4-Fluoro-benzyl)-quinolin-3-yl-amine
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases

  摘要：

  The synthesis and antimicrobial activity of new N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole ketoconazole, enilconazole and imazalil sulfate; which showed that some of the tested compounds possessed moderate activity against strains of Candida albicans, Candida sp and good activity against isolates of plant pathogenic fungi, In contrast the synthesized compounds showed poor antibacterial activity, except for 3j which exhibited a better activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.

  DOI：

  10.1016/0223-5234(96)88217-1
• 作为产物：
  描述：

  3-氨基喹啉 、 对氟苯甲醛 反应 3.0h， 以51%的产率得到[1-(4-Fluoro-phenyl)-meth-(Z)-ylidene]-quinolin-3-yl-amine
  参考文献：
  名称：

  Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases

  摘要：

  The synthesis and antimicrobial activity of new N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole ketoconazole, enilconazole and imazalil sulfate; which showed that some of the tested compounds possessed moderate activity against strains of Candida albicans, Candida sp and good activity against isolates of plant pathogenic fungi, In contrast the synthesized compounds showed poor antibacterial activity, except for 3j which exhibited a better activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.

  DOI：

  10.1016/0223-5234(96)88217-1

文献信息

• Research on antibacterial and antifungal agents. XI. Synthesis and antimicrobial activity of N-heteroaryl benzylamines and their Schiff bases
  作者：R Fioravanti、M Biava、GC Porretta、C Landolfi、N Simonetti、A Villa、E Conte、A Porta-Puglia

  DOI：10.1016/0223-5234(96)88217-1

  日期：1995.1

  The synthesis and antimicrobial activity of new N-heteroaryl benzylamines and their Schiff bases are reported. Antifungal data were compared with those obtained with miconazole ketoconazole, enilconazole and imazalil sulfate; which showed that some of the tested compounds possessed moderate activity against strains of Candida albicans, Candida sp and good activity against isolates of plant pathogenic fungi, In contrast the synthesized compounds showed poor antibacterial activity, except for 3j which exhibited a better activity than nalidixic acid used as positive control. The results obtained are discussed on the basis of structure-activity relationships.