2-[2-(8-Hydroxyquinolin-2-yl)ethenyl]quinolin-8-ol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-[2-(8-Hydroxyquinolin-2-yl)ethenyl]quinolin-8-ol
• 化学式: C₂₀H₁₄N₂O₂
• 分子量: 314.343
• InChiKey: VLHRWFKWETULPS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.2
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  8-羟基喹哪啶 、 8-羟基喹啉-2-甲醛 在 乙酸酐 作用下， 反应 40.0h， 以19.2%的产率得到2-[2-(8-Hydroxyquinolin-2-yl)ethenyl]quinolin-8-ol
  参考文献：
  名称：

  8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs)

  摘要：

  A series of 8-hydroxyquinoline derivatives with different substituted groups at 2- or 5-position have been synthesized and characterized. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSCs) have been evaluated by MTT assay and flow cytometry. We also analyzed the ability of these compounds to regulate the proliferation of rMSCs and the relationship with the structures of 8-hydroxyquinoline. Compounds 8-11, in which, the vinyl-substituents are on the 2-position of 8-hydroxyquinoline, appear to be able to induce the proliferation of rMSCs. These results show that compounds 8-11 provide a kind of new substances for regulating the proliferation of rMSCs. (c) 2006 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2006.05.004

文献信息

• 8-Hydroxyquinoline derivatives induce the proliferation of rat mesenchymal stem cells (rMSCs)
  作者：He-Ping Zeng、Ting-Ting Wang、Xin-Hua Ouyang、Ya-Dong Zhou、Hui-Lian Jing、Guo-Zan Yuan、Dong-Feng Chen、Shao-Hui Du、Hui Li、Jian-Hong Zhou

  DOI：10.1016/j.bmc.2006.05.004

  日期：2006.8

  A series of 8-hydroxyquinoline derivatives with different substituted groups at 2- or 5-position have been synthesized and characterized. Their effects on the proliferation of the rat marrow-derived mesenchymal stem cells (rMSCs) have been evaluated by MTT assay and flow cytometry. We also analyzed the ability of these compounds to regulate the proliferation of rMSCs and the relationship with the structures of 8-hydroxyquinoline. Compounds 8-11, in which, the vinyl-substituents are on the 2-position of 8-hydroxyquinoline, appear to be able to induce the proliferation of rMSCs. These results show that compounds 8-11 provide a kind of new substances for regulating the proliferation of rMSCs. (c) 2006 Elsevier Ltd. All rights reserved.