Methyl 7-chloro-3-(3,4,5-trimethylphenyl)-2,4-bis(2-trimethylsilylethoxy)quinoline-6-carboxylate | 362604-23-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: Methyl 7-chloro-3-(3,4,5-trimethylphenyl)-2,4-bis(2-trimethylsilylethoxy)quinoline-6-carboxylate
• CAS: 362604-23-7
• 化学式: C₃₀H₄₂ClNO₄Si₂
• 分子量: 572.292
• InChiKey: OQXFRHRYWABPKQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.7
• 重原子数：
  38
• 可旋转键数：
  11
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  57.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  Methyl 7-chloro-3-(3,4,5-trimethylphenyl)-2,4-bis(2-trimethylsilylethoxy)quinoline-6-carboxylate 在 lithium hydroxide 、 四丁基氟化铵 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 N,N-二异丙基乙胺 、 三苯基膦 、 三氟乙酸 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 乙醇 、 二氯甲烷 为溶剂， 生成 7-Chloro-4-(2-morpholin-3-yl-ethoxy)-2-oxo-3-(3,4,5-trimethyl-phenyl)-1,2-dihydro-quinoline-6-carboxylic acid [1,2,5]thiadiazol-3-ylamide
  参考文献：
  名称：

  Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists

  摘要：

  A series of neutral, nonbasic quinolone GnRH antagonists were prepared via Mitsunobu alkylation of protected and unprotected 4-hydroxy quinolone intermediates. The synthetic route was improved by utilization of unique reactivity and convergency afforded by the use of mono and bis-trimethylsilylethyl protected quinolones. Potent neutral GnRH antagonists were identified, including ether and lactam derivatives, that show similar in vitro binding affinity and functional activity as compared to the earlier basic 4-aminoalkyl quinolone series of nonpeptide GnRH antagonists. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.056
• 作为产物：
  描述：

  2-(三甲硅基)乙醇 、 6-carbomethoxy-7-chloro-4-hydroxy-3-(3,4,5-trimethylphenyl)-1H-quinolin-2-one 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 以99%的产率得到Methyl 7-chloro-3-(3,4,5-trimethylphenyl)-2,4-bis(2-trimethylsilylethoxy)quinoline-6-carboxylate
  参考文献：
  名称：

  Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists

  摘要：

  A series of neutral, nonbasic quinolone GnRH antagonists were prepared via Mitsunobu alkylation of protected and unprotected 4-hydroxy quinolone intermediates. The synthetic route was improved by utilization of unique reactivity and convergency afforded by the use of mono and bis-trimethylsilylethyl protected quinolones. Potent neutral GnRH antagonists were identified, including ether and lactam derivatives, that show similar in vitro binding affinity and functional activity as compared to the earlier basic 4-aminoalkyl quinolone series of nonpeptide GnRH antagonists. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.08.056

文献信息

• Identification of neutral 4-O-alkyl quinolone nonpeptide GnRH receptor antagonists
  作者：Robert J. DeVita、Mamta Parikh、Jinlong Jiang、Jason A. Fair、Jonathan R. Young、Thomas F. Walsh、Mark T. Goulet、Jane-L. Lo、Ning Ren、Joel B. Yudkovitz、Jisong Cui、Yi T. Yang、Kang Cheng、Susan P. Rohrer、Matthew J. Wyvratt

  DOI：10.1016/j.bmcl.2004.08.056

  日期：2004.11

  A series of neutral, nonbasic quinolone GnRH antagonists were prepared via Mitsunobu alkylation of protected and unprotected 4-hydroxy quinolone intermediates. The synthetic route was improved by utilization of unique reactivity and convergency afforded by the use of mono and bis-trimethylsilylethyl protected quinolones. Potent neutral GnRH antagonists were identified, including ether and lactam derivatives, that show similar in vitro binding affinity and functional activity as compared to the earlier basic 4-aminoalkyl quinolone series of nonpeptide GnRH antagonists. (C) 2004 Elsevier Ltd. All rights reserved.