3-Methoxy-6,8-dimethyl-2-(p-chlorphenyl)-4-quinaldehyde | 57464-15-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-Methoxy-6,8-dimethyl-2-(p-chlorphenyl)-4-quinaldehyde
• 英文别名: 2-(4-chloro-phenyl)-3-methoxy-6,8-dimethyl-quinoline-4-carbaldehyde；Quinoline 4-formyl-3-methoxy-6,8-dimethyl-2-[4-chlrophenyl]-；2-(4-chlorophenyl)-3-methoxy-6,8-dimethylquinoline-4-carbaldehyde
• CAS: 57464-15-0
• 化学式: C₁₉H₁₆ClNO₂
• 分子量: 325.795
• InChiKey: ATGYVLQHBUTFDC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  23
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  methylenedimethyl sulfurane 、 3-Methoxy-6,8-dimethyl-2-(p-chlorphenyl)-4-quinaldehyde 生成 2-(4-chloro-phenyl)-3-methoxy-6,8-dimethyl-4-oxiranyl-quinoline
  参考文献：
  名称：

  Antimalarials. 10. Substituted 3-halo- and 3-methoxy-2-aryl-4-quinoline(dibutylaminomethyl)methanols

  摘要：

  Four 2-aryl-4-quinoline(di-n-butylaminomethyl)methanols with Br, Cl, F, or OMe in position 3 were synthesized by modifications of standard reactions. The antimalarial activity decreased with increased size of the 3-substituent. The 3-F-4',6,8-Cl3 compound was the most active (at 2.5 mg/kg) and was completely curative at 80 mg/kg against P. berghei in mice.

  DOI：

  10.1021/jm00246a012

文献信息

• Antimalarials. 10. Substituted 3-halo- and 3-methoxy-2-aryl-4-quinoline(dibutylaminomethyl)methanols
  作者：H. Randall Munson、Richard E. Johnson、J. Milton Sanders、Cyrus J. Ohnmacht、Robert E. Lutz

  DOI：10.1021/jm00246a012

  日期：1975.12

  Four 2-aryl-4-quinoline(di-n-butylaminomethyl)methanols with Br, Cl, F, or OMe in position 3 were synthesized by modifications of standard reactions. The antimalarial activity decreased with increased size of the 3-substituent. The 3-F-4',6,8-Cl3 compound was the most active (at 2.5 mg/kg) and was completely curative at 80 mg/kg against P. berghei in mice.