6-azido-α-D-6-deoxy-glucopyranose | 138331-98-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-azido-α-D-6-deoxy-glucopyranose
• 英文别名: alpha-D-Glucopyranose, 6-azido-6-deoxy-；(2S,3R,4S,5S,6R)-6-(azidomethyl)oxane-2,3,4,5-tetrol
• CAS: 138331-98-3
• 化学式: C₆H₁₁N₃O₅
• 分子量: 205.17
• InChiKey: CMLRUUHRGSJVMD-DVKNGEFBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  105
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  6-azido-α-D-6-deoxy-glucopyranose 在 氢气 作用下， 生成 6-aminoglucose
  参考文献：
  名称：

  Glyco-S-nitrosothiols, a novel class of no donor compounds

  摘要：

  Three novel glyco-S-nitrosothiol NO donor compounds 1, 2, and 3 have been synthesized. These compounds outperform S-nitroso-N-acetylpenicillamine (SNAP) in aqueous solubility and stability, with and without EDTA and in the presence or absence of Cu2+. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00484-2
• 作为产物：
  描述：

  6-O-Tosyl-α-D-glucopyranose 在 sodium azide 作用下， 生成 6-azido-α-D-6-deoxy-glucopyranose
  参考文献：
  名称：

  Glyco-S-nitrosothiols, a novel class of no donor compounds

  摘要：

  Three novel glyco-S-nitrosothiol NO donor compounds 1, 2, and 3 have been synthesized. These compounds outperform S-nitroso-N-acetylpenicillamine (SNAP) in aqueous solubility and stability, with and without EDTA and in the presence or absence of Cu2+. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/0960-894x(96)00484-2

文献信息

• Novel drug delivery compositions
  申请人：Wiebe Leonard

  公开号：US20070021380A1

  公开（公告）日：2007-01-25

  The present invention provides for a novel molecules useful for delivery of compounds to a mammal, more particularly for the intracellular delivery of nucleotides, nucleotide analogues or compounds with a heterocyclic base. Also provided for are novel therapeutic complexes comprising novel molecules complexed with nucleotide analogues or heterogeneous or homogenous oligomers comprised of nucleotide analogues.

  本发明提供了一种新型分子，用于将化合物传递给哺乳动物，更具体地用于核苷酸、核苷酸类似物或具有杂环碱基的化合物的细胞内传递。还提供了包括与核苷酸类似物或由核苷酸类似物组成的异质或同质寡聚体形成的新型治疗复合物。
• [EN] A FUNCTIONALIZED GLYCOLIPID AND AN APPLICATION THEREOF<br/>[FR] GLYCOLIPIDE FONCTIONNALISÉ ET SON UTILISATION
  申请人：UNIV MALAYA

  公开号：WO2020204691A1

  公开（公告）日：2020-10-08

  The present invention discloses a functionalized glycolipid having a formula (I): (I) where Y is selected from a group consisting of O, NH and NAc; wherein A is selected from a group of bi-antennary hydrophobic domain having a formula (II): (II) and mono-antennary hydrophobic domain having a formula (III): (III) wherein B having a formula (IV): (IV). Further, the present invention discloses an application of the functionalized glycolipid having the formula (I) thereof. The functionalized glycolipid is usable with a drug delivery carrier for binding biological recognition domain for the cells specific recognition of the carrier via click chemistry.

  本发明揭示了一种具有公式（I）的功能化糖脂：（I），其中Y选自由O、NH和NAc组成的一组，其中A选自具有公式（II）的双天线疏水区域组和具有公式（III）的单天线疏水区域组，其中B具有公式（IV）。此外，本发明还揭示了该公式（I）的功能化糖脂的应用。该功能化糖脂可与药物输送载体一起使用，通过点击化学与细胞特异性识别载体的生物识别结构结合，以实现对载体的细胞特异性识别。
• Metabolic labeling and molecular enhancement of biological materials using bioorthogonal reactions
  申请人：The General Hospital Corporation

  公开号：US20170362266A1

  公开（公告）日：2017-12-21

  The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix (ECM) of an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal. In some aspects, the present application provides a decellularized scaffold of a mammalian organ or tissue comprising an extracellular matrix, wherein the extracellular matrix of the decellularized scaffold is functionalized with a chemical group that is reactive in a bioorthogonal chemical reaction, such as an azide chemical group. The present application also provides biological prosthetic mesh and mammalian organs and tissues for transplantation prepared according to the methods of the application.

  本申请提供了一种通过向哺乳动物投与营养物质（例如，乙酰化N-叠氮基半乳糖氨酸Ac4GalNAz）或在含有这种营养物质的生物反应器中培养器官或组织来功能化哺乳动物器官或组织的方法。本申请还提供了一种通过向哺乳动物投与营养物质（例如，乙酰化N-叠氮基半乳糖氨酸Ac4GalNAz）来选择性地功能化哺乳动物器官或组织的细胞外基质（ECM）的方法。在某些方面，本申请提供了哺乳动物器官或组织的脱细胞支架，其中脱细胞支架的细胞外基质被功能化为在生物正交化学反应中具有反应性的化学基团，例如叠氮基团。本申请还提供了根据本申请的方法制备的生物义肢网和哺乳动物器官和组织用于移植。
• [EN] SYNTHESIS OF LACTONE DERIVATIVES AND THEIR USE IN THE MODIFICATION OF PROTEINS<br/>[FR] SYNTHÈSE DE DÉRIVÉS DE LACTONE ET LEUR UTILISATION DANS LA MODIFICATION DE PROTÉINES
  申请人：GENIE BIOTECH UK LTD

  公开号：WO2021123229A1

  公开（公告）日：2021-06-24

  Site-specific modifications of proteins are desirable in biotechnological applications such as biopharmaceuticals, immunotherapy, vaccines, and are useful in chemical biology. Gluconoylation is a non-enzymatic, covalent, post-translational modification commonly observed on N-terminal His-Tags bearing proteins. We synthesized glucono-1,5-lactone derivatives, including azido variants for selective acylation. High yield acylation is achieved by simply mixing derivatives with target protein amidst diverse conditions of temperatures, aqueous buffers, excipients, or complex cell lysate.

  蛋白质的位点特异性修饰在生物技术应用中是可取的，例如生物制药、免疫疗法、疫苗，并且在化学生物学中也非常有用。葡萄糖酸化是一种非酶促的共价后翻译修饰，常见于带有N-末端His-标签的蛋白质上。我们合成了葡萄糖酸-1,5-内酯衍生物，包括用于选择性酰化的叠氮化衍生物。只需将衍生物与目标蛋白质混合在不同的温度、水溶液缓冲剂、辅料或复杂的细胞裂解液条件下，即可实现高产酰化。
• Phase transfer catalyzed glycosidation of an indolocarbazole
  申请人：——

  公开号：US20020058803A1

  公开（公告）日：2002-05-16

  The present invention relates to a novel glycosidation process to make intermediates useful in the preparation of indolopyrrolocarbazole derivatives which inhibit the growth of tumor cells and are therefore useful in the treatment of cancer in mammals, and the like.

  本发明涉及一种新型糖苷化工艺，用于制造制备吲哚吡咯并咔唑衍生物的中间体，该衍生物可抑制肿瘤细胞的生长，因此可用于治疗哺乳动物的癌症等。