2-(3,6-Diethyl-5-(4-methylpyridin-2-yloxy)pyrazin-2-ylamino)-2-phenylethanol | 960055-88-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(3,6-Diethyl-5-(4-methylpyridin-2-yloxy)pyrazin-2-ylamino)-2-phenylethanol
• 英文别名: 2-[[3,6-diethyl-5-(4-methylpyridin-2-yl)oxypyrazin-2-yl]amino]-2-phenylethanol
• CAS: 960055-88-3
• 化学式: C₂₂H₂₆N₄O₂
• 分子量: 378.474
• InChiKey: VTCADMPFZDCETP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  28
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  80.2
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-(3,6-Diethyl-5-(4-methylpyridin-2-yloxy)pyrazin-2-ylamino)-2-phenylethanol 、 alkaline earth salt of/the/ methylsulfuric acid 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 3,6-diethyl-N-(2-isopropoxy-1-phenylethyl)-5-(4-methylpyridin-2-yloxy)pyrazin-2-amine
  参考文献：
  名称：

  Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists

  摘要：

  Low nanomolar corticotropin releasing factor type-1 (CRF1) receptor antagonists containing unique indanylamines were identified from the heteroatom-linked pyrazine chemotype. The most potent indanylpyrazine had a K-i = 11 +/- 1 nM. The oxygen-linked pyrazinyl derivatives were prepared through a copper-catalyzed coupling of a pyridinone to a bromo- or iodopyrazine. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.008
• 作为产物：
  描述：

  2-羟基-4-甲基吡啶 、 在 copper(l) iodide 、 caesium carbonate 、 N,N'-二甲基乙二胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 2-(3,6-Diethyl-5-(4-methylpyridin-2-yloxy)pyrazin-2-ylamino)-2-phenylethanol
  参考文献：
  名称：

  Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists

  摘要：

  Low nanomolar corticotropin releasing factor type-1 (CRF1) receptor antagonists containing unique indanylamines were identified from the heteroatom-linked pyrazine chemotype. The most potent indanylpyrazine had a K-i = 11 +/- 1 nM. The oxygen-linked pyrazinyl derivatives were prepared through a copper-catalyzed coupling of a pyridinone to a bromo- or iodopyrazine. (C) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2007.09.008

文献信息

• Heteroatom-linked indanylpyrazines are corticotropin releasing factor type-1 receptor antagonists
  作者：Jeffrey W. Corbett、Mark R. Rauckhorst、Fang Qian、Robert L. Hoffman、Christopher S. Knauer、Lawrence W. Fitzgerald

  DOI：10.1016/j.bmcl.2007.09.008

  日期：2007.11

  Low nanomolar corticotropin releasing factor type-1 (CRF1) receptor antagonists containing unique indanylamines were identified from the heteroatom-linked pyrazine chemotype. The most potent indanylpyrazine had a K-i = 11 +/- 1 nM. The oxygen-linked pyrazinyl derivatives were prepared through a copper-catalyzed coupling of a pyridinone to a bromo- or iodopyrazine. (C) 2007 Elsevier Ltd. All rights reserved.