1-p-tolyl-1,2-dihydro-2-quinolone | 117727-00-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-p-tolyl-1,2-dihydro-2-quinolone
• 英文别名: 1-(p-Tolyl)-1,2-dihydroquinolin-2-one；1-(p-tolyl)quinolin-2(1H)-one；1-(p-tolyl)-1H-quinolin-2-one；1-(4-methylphenyl)quinolin-2-one
• CAS: 117727-00-1
• 化学式: C₁₆H₁₃NO
• 分子量: 235.285
• InChiKey: BWLDXWQJXXYBQV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  N-(4-甲基苯基)-3-苯基丙烯酰胺 在 bis[3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridyl]phenyl]iridium(1+); 2-(2-pyridyl)pyridine; hexafluorophosphate 、 tributylmethylammonium dibutyl phosphate 作用下， 以 1,2-二氯乙烷 为溶剂， 以65%的产率得到1-p-tolyl-1,2-dihydro-2-quinolone
  参考文献：
  名称：

  Visible-Light-Photocatalyzed Synthesis of Phenanthridinones and Quinolinones via Direct Oxidative C–H Amidation

  摘要：

  A straightforward synthetic strategy to construct biologically relevant phenanthridinones and quinolinones was developed via visible-light-promoted direct oxidative C-H amidation. In this photocatalytic system, amidyl radicals can be generated by homolysis of the N-H bond of simple amide precursors via single-electron transfer under blue LED illumination, which leads to oxidative intramolecular C-H amidation. Moreover, an efficient synthetic strategy using a photocascade enabled facile assembly of quinolinone structures through a catalytic sequence involving triplet energy (E-T) transfer based E/Z olefin isomerization and subsequent photocatalytic generation of amidyl radical intermediates.

  DOI：

  10.1021/acs.orglett.7b03600

文献信息

• Lopez-Alvarado, Pilar; Avendano, Carmen; Menendez, J. Carlos, Journal of the Chemical Society. Perkin transactions I, 1997, # 3, p. 229 - 233
  作者：Lopez-Alvarado, Pilar、Avendano, Carmen、Menendez, J. Carlos

  DOI：——

  日期：——
• WAWZONEK, STANLEY;TRUONG, THIEN VAN, J. HETEROCYCL. CHEM., 25,(1988) N 2, C. 381-382
  作者：WAWZONEK, STANLEY、TRUONG, THIEN VAN

  DOI：——

  日期：——
• Wawzonek, Stanley; Truong, Thien Van, Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 381 - 382
  作者：Wawzonek, Stanley、Truong, Thien Van

  DOI：——

  日期：——
• [EN] AZA-BENZAZOLIUM CONTAINING CYANINE DYES<br/>[FR] COLORANTS CYANINES CONTENANT DE L'AZA-BENZOLIUM
  申请人：MOLECULAR PROBES INC

  公开号：WO2000066664A1

  公开（公告）日：2000-11-09

  Unsymmetrical cyanine dyes that incorporate an aza-benzazolium ring moiety are described, including cyanine dyes substituted by a cationic side chain, monomeric and dimeric cyanine dyes, chemically reactive cyanine dyes, and conjugates of cyanine dyes. The subject dyes are virtually non-fluorescent when diluted in aqueous solution, but exhibit bright fluorescence when associated with nucleic acid polymers such as DNA or RNA, or when associated with detergent-complexed proteins. A variety of applications are described for detection and quantitation of nucleic acids and detergent-complexed proteins in a variety of samples, including solutions, electrophoretic gels, cells, and microorganisms.
• [EN] FLUORESCENT COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSÉS FLUORESCENTS ET UTILISATION DE CEUX-CI
  申请人：BIOTIUM INC

  公开号：WO2014005125A2

  公开（公告）日：2014-01-03

  The invention provides compounds, including fluorescent nucleic acid dyes, and methods for use including nucleic acid detection, nucleic acid amplification reactions, and high-resolution melt curve analysis. Further provided are kits, instruments and systems comprising compounds of the invention or adapted for use with compounds of the invention or other nucleic acid dyes.