(4R,5R)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)oxazolidin-2-one | 1613057-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (4R,5R)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)oxazolidin-2-one
• 英文别名: (4R,5R)-5-(aminomethyl)-3-(3-fluoro-4-morpholin-4-ylphenyl)-4-(4-methoxyphenyl)-1,3-oxazolidin-2-one
• CAS: 1613057-81-0
• 化学式: C₂₁H₂₄FN₃O₄
• 分子量: 401.438
• InChiKey: SKPLLNYHKDQMRY-WOJBJXKFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  77.3
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (4R,5R)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)oxazolidin-2-one 、 乙酸酐 在 4-二甲氨基吡啶 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 以85%的产率得到N-(((4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-2-oxooxazolidin-5-yl)methyl)acetamide
  参考文献：
  名称：

  Oxazolidinone derivatives: Cytoxazone–Linezolid hybrids induces apoptosis and senescence in DU145 prostate cancer cells

  摘要：

  In this study, we report the synthesis of novel oxazolidinone derivatives derived from linezolid 3 having p-methoxyphenyl group at C-4 position. In vitro evaluation for their anticancer activity toward cultured A549, DU145, HELA, and MCF7 were carried out. The series of compounds prepared displayed wide range of cytotoxicity in MTT assays (10-70 μM) across the cell lines tested. Of the all tested compounds 16 and 17 displayed good anticancer potential against A549 (lung) and DU145 (prostate) cancer cells. Further, to determine their anticancer potential, in the present study we have assessed effect of 17 on DU145 cells growth in in vitro assays. The results clearly demonstrated that the exposure of DU145 cells to 17 inhibits cell proliferation and induces apoptosis by activation of caspase-3 and -9. Long term exposure of DU145 cells to 17 induced cellular senescence confirmed by senescence marker β-galactosidase staining of cells on post exposure to 17. The results from this current report support that the oxazolidinone derivatives with ethyl and acryl substitutions showed promising anticancer activity which will be helpful to develop further novel anticancer agents with better therapeutic potential.

  DOI：

  10.1016/j.ejmech.2014.04.062
• 作为产物：
  描述：

  3-氟-4-(4-吗啉基)苯胺 在 4-二甲氨基吡啶 、 copper(l) iodide 、 sodium azide 、 palladium 10% on activated carbon 、 氢气 、 caesium carbonate 、 对甲苯磺酸 、 臭氧 、 三乙胺 、 potassium iodide 、 N,N'-二甲基乙二胺 、 sodium nitrite 作用下， 以 1,4-二氧六环 、 甲醇 、 二氯甲烷 、 水 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 11.67h， 生成 (4R,5R)-5-(aminomethyl)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)oxazolidin-2-one
  参考文献：
  名称：

  Oxazolidinone derivatives: Cytoxazone–Linezolid hybrids induces apoptosis and senescence in DU145 prostate cancer cells

  摘要：

  In this study, we report the synthesis of novel oxazolidinone derivatives derived from linezolid 3 having p-methoxyphenyl group at C-4 position. In vitro evaluation for their anticancer activity toward cultured A549, DU145, HELA, and MCF7 were carried out. The series of compounds prepared displayed wide range of cytotoxicity in MTT assays (10-70 μM) across the cell lines tested. Of the all tested compounds 16 and 17 displayed good anticancer potential against A549 (lung) and DU145 (prostate) cancer cells. Further, to determine their anticancer potential, in the present study we have assessed effect of 17 on DU145 cells growth in in vitro assays. The results clearly demonstrated that the exposure of DU145 cells to 17 inhibits cell proliferation and induces apoptosis by activation of caspase-3 and -9. Long term exposure of DU145 cells to 17 induced cellular senescence confirmed by senescence marker β-galactosidase staining of cells on post exposure to 17. The results from this current report support that the oxazolidinone derivatives with ethyl and acryl substitutions showed promising anticancer activity which will be helpful to develop further novel anticancer agents with better therapeutic potential.

  DOI：

  10.1016/j.ejmech.2014.04.062