5-乙氧基噁唑 | 15031-12-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 5-乙氧基噁唑
• 英文名称: 5-ethoxyoxazole
• 英文别名: 5-ethoxy-oxazole；5-Aethoxy-oxazol；5-Aethoxypyrazol；5-Aethoxyoxazol；5-Ethoxy-oxazol；5-Ethoxyoxazol；5-ethoxy-1,3-oxazole
• CAS: 15031-12-6
• 化学式: C₅H₇NO₂
• 分子量: 113.116
• InChiKey: BNMZAQRFVVJHOT-UHFFFAOYSA-N

物化性质

• 沸点：
  74 °C(Press: 35 Torr)
• 密度：
  1.067±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  35.3
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 海关编码：
  2934999090

反应信息

• 作为反应物：
  描述：

  5-乙氧基噁唑 、 三氟甲烷磺酸甲酯 以 乙腈 为溶剂， 反应 2.0h， 生成
  参考文献：
  名称：

  4-恶唑啉途径稳定偶氮甲碱叶立德。恶唑盐的受控还原

  摘要：

  练习曲, en particulier de l'effet des substituants de l'oxazole de leave sur les produits obtenus

  DOI：

  10.1021/ja00218a038
• 作为产物：
  描述：

  5-乙氧基-2-恶唑羧酸 反应 0.5h， 生成 5-乙氧基噁唑
  参考文献：
  名称：

  Kozikowski,A.P.; Isobe,K., Heterocycles, 1978, vol. 9, p. 1271 - 1275

  摘要：

  DOI：

文献信息

• Pyridopyridazine compounds and their use
  申请人：Takeda Chemical Industries, Ltd.

  公开号：US05420275A1

  公开（公告）日：1995-05-30

  An assay method which comprises utilizing chemiluminescence of a pyridopyridazine compound of the formula ##STR1## wherein R.sub.1 is a hydrocarbon group or a heterocyclic group each of which may be substituted and R.sub.2 is hydroxy group, thiol group, amino group or a monosubstituted amino group, and when R.sub.2 is a monosubstituted amino group, R.sub.2 may be taken together with R.sub.1 to form the ring; R.sub.3 is hydrogen atom, a hydroxy group which may be substituted, an amino group which may be substituted, a thiol group which may be substituted, a halogen atom, a heterocyclic group, nitro group, cyano group, carboxyl group which may be esterified or amidated, azido group, sulfo group or an organic sulfonyl group, provided that when R.sub.1 is an aliphalic group, R.sub.3 is not hydrogen atom; and X is oxygen atom or sulfur atom/or a salt thereof; and a novel compound of the formula (I) wherein the symbols are as defined above with proviso that R.sub.3 is hydrogen atom, R.sub.1 is a substituted aryl group or a heterocyclic group which may be substituted, or a salt thereof and the production methods thereof.

  一种测定方法，包括利用式中的吡啶吡啶二氮化合物的化学发光##STR1##，其中R.sub.1是一个烃基或杂环基，每个基可能被取代，R.sub.2是羟基、硫醇基、氨基或单取代氨基，当R.sub.2是单取代氨基时，R.sub.2可以与R.sub.1一起形成环；R.sub.3是氢原子、可能被取代的羟基、可能被取代的氨基、可能被取代的硫醇基、卤素原子、杂环基、硝基、氰基、可能被酯化或酰胺化的羧基、叠氮基、磺酰基或有机磺酰基，但当R.sub.1是脂肪族基时，R.sub.3不是氢原子；X是氧原子或硫原子/或其盐；以及式(I)的新化合物，其中符号如上所定义，但R.sub.3是氢原子，R.sub.1是取代芳基或可能被取代的杂环基，或其盐以及其生产方法。
• Thermal elimination reactions of nitrogen and sulphur heterocycles
  作者：R. Grigg、R. Hayes、J. L. Jackson

  DOI：10.1039/c29690001167

  日期：——

  hydrogen cyanide and nitriles in retro-diene and retro-homocycloadditions are reported and attention drawn to combined electrocyclic–cheletropic processes occurring in nitrogen- and sulphur-containing heterocycles.

  据报道，在逆二烯和逆全杂环加成中消除了氰化氢和腈，并引起了人们对含氮和硫的杂环中发生的电致循环综合过程的关注。
• Peroxisome proliferator-activated receptor-γ mediates the anti-inflammatory effect of 3-hydroxy-4-pyridinecarboxylic acid derivatives: Synthesis and biological evaluation
  作者：Paola Brun、Annalisa Dean、Valerio Di Marco、Pathak Surajit、Ignazio Castagliuolo、Davide Carta、Maria Grazia Ferlin

  DOI：10.1016/j.ejmech.2013.01.024

  日期：2013.4

  Seven 3-hydroxy-4-pyridinecarboxylic acid derivatives (HPs), aza-analogues of salicylic acid and structurally close to other potent inflammatory pyridine compounds such as aminopyridinylmethanols and aminopyridinamines, were synthesized, and their anti-inflammatory activity was evaluated. The synthesis was performed by adopting a general procedure involving an intramolecular Diels-Alder cycloaddition of oxazoles with acrylic acid to form various substituted pyridinic acids. The newly synthesized HPs did not exhibit cytotoxic activity on human monocytes-derived macrophages at concentrations up to 10(2) mu M. Anti-inflammatory activity of the compounds was screened in vitro by evaluating the capability to inhibit cytokines release from lipopolysaccharide (LPS) stimulated human macrophages. 3-Hydroxy-1-methyl-4-pyridinecarboxylic acid (24) was found to be the most active HP. At 10 mu M concentration, HP 24 reduced LPS-induced and nuclear factor-kappa B activation and cyclooxygenase-2 expression, while increased intracellular reactive oxygen species generation and peroxisome proliferator-activated receptor (PPAR-gamma) mRNA transcript level. Indeed, pre-treatment of LPS-exposed human macrophages with PPAR-gamma specific antagonist completely prevented HP 24-induced TNF-alpha and IL8 down regulation, demonstrating that the PPAR gamma pathway is mandatory for the HP 24 anti-inflammatory effect. Finally, daily treatment with HP 24 ameliorated the outcome of DSS-induced colitis in mice, significantly reducing colonic MPO activity and IL-1 beta tissue levels. (C) 2013 Elsevier Masson SAS. All rights reserved.
• Johnsen, Bjoern A.; Undheim, Kjell, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1983, vol. 37, # 2, p. 127 - 132
  作者：Johnsen, Bjoern A.、Undheim, Kjell

  DOI：——

  日期：——
• SEITZ, GUNTHER;MOHR, ROLF;HOFERICHTER, REINHARD, CHEM.-ZTG., 113,(1989) N, C. 17-18
  作者：SEITZ, GUNTHER、MOHR, ROLF、HOFERICHTER, REINHARD

  DOI：——

  日期：——