申请人:AMGEN INC.
公开号:US20140045855A1
公开(公告)日:2014-02-13
Chroman compounds and derivatives of Formula I are useful inhibitors of TRPM8. Such compounds are useful in treating a number of TRPM8 mediated disorders and conditions and may be used to prepare medicaments and pharmaceutical compositions useful for treating such disorders and conditions. Examples of such disorders include, but are not limited to, migraines and neuropathic pain. Compounds of Formula I have the following structure:
where the definitions of the variables are provided herein.
Formula I的Chroman化合物和衍生物是TRPM8的有用抑制剂。这些化合物在治疗多种由TRPM8介导的疾病和症状方面具有用途,并可用于制备治疗这些疾病和症状的药物和药物组合物。这些疾病的例子包括,但不限于,偏头痛和神经病性疼痛。Formula I的化合物具有以下结构:变量的定义在此提供。