p-methoxycinnamic acid sodium salt | 83168-89-2

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: p-methoxycinnamic acid sodium salt
• 英文别名: sodium-p-methoxycinnamate；Sodium p-methoxy-trans-cinnamate；sodium (E)-3-(4-methoxyphenyl)acrylate；sodium trans-4-methoxycinnamate；Sodium p-methoxycinnamate；sodium;(E)-3-(4-methoxyphenyl)prop-2-enoate
• CAS: 83168-89-2
• 化学式: C₁₀H₉O₃*Na
• 分子量: 200.169
• InChiKey: VOKPJLHFFYVQNS-KQGICBIGSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.54
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  p-methoxycinnamic acid sodium salt 、 2-氨基苯硫醇 以76%的产率得到2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  参考文献：
  名称：

  Solid Phase Synthesis of Hydroxy Benzothiazepinones through Cyclative Release under Thermolysis

  摘要：

  羟基苯并硫氮杂酮通过简单的程序合成，包括聚合物结合的肉桂酸的环氧化，然后通过邻氨基苯硫酚对所得缩水甘油酯进行亲核开环，得到中间体羟基苯胺基酯，该中间体在DMF中加热时进行环化裂解，以完全释放产物。

  DOI：

  10.1246/cl.2004.888
• 作为产物：
  描述：

  反式-4-甲氧基肉桂酸 在 sodium hydroxide 作用下， 以 甲醇 、 水 为溶剂， 反应 0.5h， 生成 p-methoxycinnamic acid sodium salt
  参考文献：
  名称：

  Production of Luminescent Europium(III) Compounds with para-Methoxycinnamic Acid

  摘要：

  DOI：

  10.1134/s1070427222040085
• 作为试剂：
  描述：

  2,4,6-三羟基苯乙酮一水合物 、 (E)-3-(4-methoxyphenyl)acrylic anhydride 在 p-methoxycinnamic acid sodium salt 作用下， 生成 5,7-bis-(4-methoxy-trans-cinnamoyloxy)-2-(4-methoxy-trans-styryl)-chromen-4-one
  参考文献：
  名称：

  Cheema et al., Journal of the Chemical Society, 1932, p. 925,930

  摘要：

  DOI：

文献信息

• SKIN EXTERNAL PREPARATIONS AND COSMETICS
  申请人：Aoki Hirobumi

  公开号：US20100280111A1

  公开（公告）日：2010-11-04

  An object of the present invention is to provide skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent formulation stability. A skin external preparation of the present invention includes a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and an amphoteric surfactant. In Formula (1), R 1 and R 2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R 1 and R 2 are the same as in Formula (1), X − is a specific anion and Y + is a specific cation.

  本发明的一个目的是提供含有支链酰基肉碱并具有优异配方稳定性的皮肤外用制剂和化妆品。本发明的皮肤外用制剂包括以下式（1）所表示的肉碱衍生物和/或以下式（2）所表示的肉碱衍生物盐，以及一种两性表面活性剂。在式（1）中，R1和R2分别独立地是C1-18的可选支链、饱和或不饱和脂肪烃基。在式（2）中，R1和R2与式（1）中相同，X−是特定的阴离子，Y+是特定的阳离子。
• Cysteine derivatives
  申请人：AJINOMOTO CO., INC.

  公开号：US20020115723A1

  公开（公告）日：2002-08-22

  Objects of the present invention are to provide an oxidative stress inhibitor which is capable of suppressing the expression of a cytotoxic protein and the activation of a gene transcriptional regulatory factor taking part such expression of a cytotoxic protein and exhibits good feeling upon use and safety; to provide a method for preventing, retarding, alleviating or treating a skin change due to aging or an undesirable aesthetic skin change, both caused or promoted by an oxidative stress; and to provide a cosmetic composition or dermatologic preparation for external use comprising the oxidative stress inhibitor as an effective ingredient, and for those purposes are employed an oxidative stress inhibiting agent which comprises, as an effective ingredient, at least one selected from cysteine or cystine derivatives and the salts thereof.

  本发明的目的是提供一种能够抑制细胞毒蛋白表达和基因转录调节因子激活的氧化应激抑制剂，该抑制剂在使用时具有良好的感觉和安全性；提供一种预防、延缓、缓解或治疗由氧化应激引起或促进的皮肤老化或不良美容皮肤变化的方法；提供一种含有氧化应激抑制剂作为有效成分的用于外用的化妆品组合物或皮肤科制剂。为了实现这些目的，使用一种氧化应激抑制剂，其有效成分包括至少一种来自半胱氨酸或半胱氨酸衍生物及其盐的物质。
• [EN] EXTERNAL PREPARATION FOR SKIN<br/>[FR] PREPARATION EXTERNE POUR LA PEAU
  申请人：SHOWA DENKO KK

  公开号：WO2005094777A1

  公开（公告）日：2005-10-13

  The present invention provides an external preparation for skin, which comprises a multi-branched polysaccharide derivative with multi-branched polysaccharide skeleton consisting of saccharides as constituent units, wherein at least one of hydroxyl (OH) groups in the multi-branched polysaccharide skeleton is substituted by OR (wherein R represents a hydrogen atom, a hydrocarbon having 1 to 30 carbon groups or a hydrocarbon having 1 to 30 carbon groups which has hetero atom), which can give moisture and turgor to the skin, and cosmetics containing the external preparation.

  本发明提供了一种用于皮肤的外用制剂，其包括一种多支链多糖衍生物，该多支链多糖骨架由糖组成的多支链多糖骨架组成，其中多支链多糖骨架中的至少一个羟基（OH）被取代为OR（其中R代表氢原子、具有1至30个碳基团的碳氢化合物或具有1至30个碳基团的碳氢化合物，其具有杂原子），可以为皮肤提供水分和弹性，并且含有该外用制剂的化妆品。
• Nickel-Catalyzed Direct Carboxylation of Olefins with CO₂: One-Pot Synthesis of α,β-Unsaturated Carboxylic Acid Salts
  作者：Núria Huguet、Ivana Jevtovikj、Alvaro Gordillo、Michael L. Lejkowski、Ronald Lindner、Miriam Bru、Andrey Y. Khalimon、Frank Rominger、Stephan A. Schunk、Peter Hofmann、Michael Limbach

  DOI：10.1002/chem.201405528

  日期：2014.12.15

  The nickel‐catalyzed direct carboxylation of alkenes with the cheap and abundantly available C1 building block carbon dioxide (CO2) in the presence of a base has been achieved. The one‐pot reaction allows for the direct and selective synthesis of a wide range of α,β‐unsaturated carboxylates (TON>100, TOF up to 6 h−1, TON=turnover number, TOF=turnover frequency). Thus, it is possible, in one step, to

  在碱的存在下，已经实现了镍的烯烃与便宜且可大量利用的C 1结构单元二氧化碳（CO 2）的镍直接催化羧化反应。一锅法反应可直接和选择性地合成各种α，β-不饱和羧酸盐（TON> 100，TOF高达6 h -1，TON =周转数，TOF =周转频率）。因此，可以在一个步骤中由乙烯，CO 2和钠盐合成丙烯酸钠。丙烯酸酯是工业上重要的产品，迄今为止其合成需要多个步骤。
• EMULSION PREPARATION FOR EXTERNAL APPLICATION TO SKIN AND COSMETIC PREPARATION
  申请人：Showa Denko K.K.

  公开号：EP2238970A1

  公开（公告）日：2010-10-13

  An object of the present invention is to provide emulsified skin external preparations and cosmetics which contain a branched acyl carnitine and have excellent emulsion stability. An emulsified skin external preparation according to the present invention includes 0.01 to 10% by mass of a carnitine derivative represented by the following Formula (1) and/or a carnitine derivative salt represented by the following Formula (2), and 0.01 to 20% by mass of a nonionic surfactant. In Formula (1), R1 and R2 are each independently a C1-18 optionally branched, saturated or unsaturated aliphatic hydrocarbon group. In Formula (2), R1 and R2 are the same as in Formula (1), X- is a specific anion and Y+ is a specific cation.

  本发明的一个目的是提供含有支链酰基肉碱且具有优异乳化稳定性的乳化皮肤外用制剂和化妆品。根据本发明的乳化皮肤外用制剂包括下列式（1）所表示的肉碱衍生物和/或下列式（2）所表示的肉碱衍生物盐，以及非离子表面活性剂，其质量百分含量分别为0.01至10%和0.01至20%。在式（1）中，R1和R2各自独立地是C1-18的可选支链、饱和或不饱和脂肪烃基。在式（2）中，R1和R2与式（1）中相同，X-是特定阴离子，Y+是特定阳离子。