Butyl cinnamoylpyruvate | 7528-05-4

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Butyl cinnamoylpyruvate
• 英文别名: butyl (E)-2,4-dioxo-6-phenylhex-5-enoate
• CAS: 7528-05-4
• 化学式: C₁₆H₁₈O₄
• 分子量: 274.31
• InChiKey: HEIBHROOHCJHCD-MDZDMXLPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  60.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• Allantoin-containing preparations for administration as gels and aerosols
  申请人：Alwyn Company, Inc.

  公开号：US20030147968A1

  公开（公告）日：2003-08-07

  Allantoin-containing preparations are prepared in a form suitable for administration as gels and aerosols. In one embodiment of the aerosol formulation, an allantoin-containing composition comprises: (1) water; (2) allantoin in a therapeutically effective quantity; (3) an anionic ethoxylated surfactant; (4) lanolin oil; and (5) cod liver oil. The composition has a viscosity and surface tension in a range that allows the composition to be administered to the skin of a user as an aerosol by a mechanical spray pump. In another aspect of this invention, the allantoin-containing preparations are prepared in a form suitable for administration as gels. The compositions can be substantially anhydrous or can contain water. In one embodiment of the gel formation, an allantoin-containing composition comprises: (1) allantoin in a therapeutically effective quantity; (2) a complex comprising mineral oil and at least one hydrogenated alkylene copolymer; (3) lanolin oil; and (4) cod liver oil. The compositions can comprise other ingredients. Compositions according to the present invention are suitable for the treatment of a number of skin conditions or diseases characterized by ulceration, inflammation, or blistering of the skin, such as epidermolysis bullosa.

  含有尿囊素的制剂以适合作为凝胶和气雾剂的形式制备。在气雾剂配方的一个实施例中，含有尿囊素的组合物包括：（1）水；（2）疗效有效量的尿囊素；（3）阴离子乙氧基化表面活性剂；（4）羊毛脂油；和（5）鱼肝油。该组合物具有粘度和表面张力范围，使得通过机械喷雾泵将组合物作为气雾施用到用户皮肤上。在这项发明的另一个方面，含有尿囊素的制剂以适合作为凝胶的形式制备。这些组合物可以是几乎无水的，也可以含水。在凝胶形成的一个实施例中，含有尿囊素的组合物包括：（1）疗效有效量的尿囊素；（2）包括矿物油和至少一种氢化烷烯共聚物的复合物；（3）羊毛脂油；和（4）鱼肝油。这些组合物可以包含其他成分。根据本发明的组合物适用于治疗一系列皮肤状况或疾病，其特征是皮肤溃疡、炎症或水疱，如表皮溶解性水疱症。
• METHOD FOR PURIFYING PYRUVIC ACID COMPOUNDS
  申请人：SUMITOMO CHEMICAL COMPANY LIMITED

  公开号：EP0937703A1

  公开（公告）日：1999-08-25

  The present invention is directed to a method for purifying pyruvic acid compounds, which method comprises reacting a pyruvic acid compound of general formula (I): wherein R1 is an optionally substituted lower alkyl group, a lower alkenyl group, a lower alkynyl group, a cycloalkyl group, an aryl group, or a heterocyclic group, and R2 is a lower alkyl group, with a bisulfite of general formula (II):         MHSO3     (II) wherein M is NH4 or an alkali metal, to give a bisulfite adduct of the pyruvic acid compound and then decomposing the adduct with an acid. According to the present invention, pyruvic acid compounds can be purified by simple and easy procedures without using purification techniques such as distillation or column chromatography, and the above method is advantageous as a process for the production on an industrial scale.

  本发明涉及一种纯化丙酮酸化合物的方法，该方法包括使通式(I)的丙酮酸化合物反应： 其中 R1 是任选取代的低级烷基、低级烯基、低级炔基、环烷基、芳基或杂环基，R2 是低级烷基，与通式（II）的亚硫酸氢盐反应： MHSO3 (II) 其中 M 为 NH4 或碱金属，以得到丙酮酸化合物的亚硫酸氢盐加合物，然后用酸分解该加合物。根据本发明，丙酮酸化合物可以通过简单易行的程序进行纯化，而无需使用蒸馏或柱层析等纯化技术，上述方法作为一种工业规模的生产工艺是非常有利的。
• Multi-tiered, high through-put screen for compounds effective against bacterial biofilm compounds effective for inhibiting and eradicating bacterial biofilm
  申请人：University of Cincinnati

  公开号：US10202631B2

  公开（公告）日：2019-02-12

  A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include as says for total bacterial growth, bacterial metabolic activity, and biofilm formation.

  本发明公开了一种高通量筛选方法，用于确定可有效抑制生物膜形成和/或杀死已形成的生物膜的制剂。该方法包括三个层级，每个层级包括三个特定的生物过程检测。层级为初筛、确认筛和剂量反应筛，生物过程测定包括细菌生长总量、细菌代谢活性和生物膜形成。
• Multi-tiered high through-put screen for compounds effective against bacterial biofilm and compounds effective for inhibiting and eradicating bacterial biofilm
  申请人：University of Cincinnati

  公开号：US10704076B2

  公开（公告）日：2020-07-07

  A high through-put screening method for identifying agents effective for inhibiting biofilm formation and/or killing established biofilm are disclosed. The method includes three tiers, and each tier includes three specific biological process assays. The tier levels are a primary screen, a confirmation screen, and a dose-response screen, and the biological process assays include assays for total bacterial growth, bacterial metabolic activity, and biofilm formation. The series of assays may be run once or more than once at each tier. A library of compounds is subject to tier A and only compounds meeting a primary parameter advance to tier B, and only tier B compounds meeting a confirmation parameter advance to tier C, and only tier C compounds meeting a dose-response parameter are identified as putative agents effective for inhibiting and/or eradicating a biofilm, further wherein the assays are conducted for each compound subject to the respective tier. The method is effective and validated for identifying agents which inhibit and/or kill Staphylococcus epidermidis, Pseudomonas aeruginosa, and Acinetobacter baumannii biofilms. Agents identified according to the high through-put screen and validated in follow-up experiments as effective for inhibiting and/or killing bacterial biofilms are also disclosed.

  本发明公开了一种高通量筛选方法，用于确定可有效抑制生物膜形成和/或杀死已形成的生物膜的制剂。该方法包括三个层级，每个层级包括三个特定的生物过程检测。层级为初筛、确认筛和剂量反应筛，生物过程测定包括细菌总生长、细菌代谢活性和生物膜形成测定。一系列检测可在每个层级进行一次或多次。将化合物库分为 A 层，只有符合主要参数的化合物才能进入 B 层，只有符合确认参数的 B 层化合物才能进入 C 层，只有符合剂量-反应参数的 C 层化合物才能被鉴定为对抑制和/或消除生物膜有效的假定制剂。该方法对于鉴定抑制和/或杀死表皮葡萄球菌、铜绿假单胞菌和鲍曼不动杆菌生物膜的制剂是有效的，也是经过验证的。还公开了根据高通量筛选确定并在后续实验中验证可有效抑制和/或杀死细菌生物膜的制剂。
• Methods for treatment of inflammatory diseases
  申请人：——

  公开号：US20020055531A1

  公开（公告）日：2002-05-09

  An improved method of treating skin diseases comprises applying to the skin of a patient suffering such a skin disease an allantoin-containing composition in a therapeutically effective quantity. The allantoin-containing composition is an oil-in-water emulsion that includes allantoin and an emulsifier system that includes at least one emulsifier that is either an anionic emulsifier or a nonionic emulsifier. If the emulsifier is an anionic emulsifier, the emulsifier system can include an acidic wax such as beeswax. The nonionic emulsifiers used can include at least one nonionic emulsifier that is an ethoxylated ether or an ethoxylated ester whose carbon chain length ranges from 8 to 22 carbon atoms. Alternatively, the emulsifier system can include an acidic anionic polymer such as carboxypolymethylene and an anionic emulsifier. In another alternative, the emulsifier system can include the acidic anionic polymer and a nonionic emulsifier, or the acidic anionic polymer alone. In still another alternative, the emulsifier system can include cetyl alcohol and stearic acid. In yet another alternative, the emulsifier system can include sodium stearoyl lactylate and sodium isostearoyl lactylate. In another alternative, the emulsifier system can include at least one polyethyleneglycol ether of cetearyl alcohol. In still another alternative, the emulsifier system can include a polyethylene glycol ester of stearic acid and glyceryl stearate. The composition can include other ingredients. The pH of the composition used in a method according to the present invention is from about 3.0 to about 6.0; preferably, a narrower pH range is used, varying with each embodiment of the composition. Among the diseases that can be treated is epidermolysis bullosa.

  一种治疗皮肤病的改进方法包括向皮肤病患者的皮肤施用治疗有效量的含尿囊素的组合物。这种含尿囊素的组合物是一种水包油型乳剂，它包括尿囊素和一种乳化剂体系，该体系包括至少一种乳化剂，这种乳化剂可以是阴离子乳化剂，也可以是非离子乳化剂。如果乳化剂是阴离子乳化剂，乳化剂体系可包括酸性蜡，如蜂蜡。所用的非离子乳化剂可包括至少一种非离子乳化剂，它是一种乙氧基化醚或乙氧基化酯，其碳链长度范围为 8 至 22 个碳原子。或者，乳化剂体系可以包括酸性阴离子聚合物，如羧基聚亚甲基和阴离子乳化剂。另一种选择是，乳化剂体系可包括酸性阴离子聚合物和非离子乳化剂，或仅包括酸性阴离子聚合物。还有一种选择是，乳化剂体系可以包括十六烷基醇和硬脂酸。在另一种选择中，乳化剂体系可包括硬脂酰乳酰酸钠和异硬脂酰乳酰酸钠。在另一种选择中，乳化剂体系可以包括至少一种鲸蜡硬脂醇聚乙二醇醚。还有一种选择是，乳化剂体系可以包括硬脂酸聚乙二醇酯和硬脂酸甘油酯。组合物还可以包括其他成分。根据本发明的方法使用的组合物的 pH 值为约 3.0 至约 6.0；优选使用较窄的 pH 值范围，随组合物的每个实施方案而变化。可治疗的疾病包括表皮松解症。