p-Methylmercapto-benzalmalonsaeurediethylester | 21980-06-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: p-Methylmercapto-benzalmalonsaeurediethylester
• 英文别名: 4'-methylmercaptobenzylidenemalonic acid diethyl ester；Diethyl 2-[[4-(methylthio)phenyl]methylene]propanedioate；diethyl 2-[(4-methylsulfanylphenyl)methylidene]propanedioate
• CAS: 21980-06-3
• 化学式: C₁₅H₁₈O₄S
• 分子量: 294.372
• InChiKey: MQONNZMFYJTYMF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  20
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  77.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  p-Methylmercapto-benzalmalonsaeurediethylester 在 氢氧化钾 作用下， 以 乙醇 为溶剂， 生成 3-(4-甲基硫烷基-苯基)-3-苯基-丙酸
  参考文献：
  名称：

  取代的2,2-二苯乙胺的合成及其肾上腺皮质激素抑制活性。

  摘要：

  DOI：

  10.1021/jm00301a003
• 作为产物：
  描述：

  4-(甲基巯基)苯甲醛 、 丙二酸二乙酯 生成 p-Methylmercapto-benzalmalonsaeurediethylester
  参考文献：
  名称：

  取代的2,2-二苯乙胺的合成及其肾上腺皮质激素抑制活性。

  摘要：

  DOI：

  10.1021/jm00301a003

文献信息

• Mechanochemical Copper‐Catalyzed Asymmetric Michael‐Type Friedel–Crafts Alkylation of Indoles with Arylidene Malonates
  作者：Plamena Staleva、José G. Hernández、Carsten Bolm

  DOI：10.1002/chem.201901826

  日期：2019.7.11

  asymmetric Michael‐type Friedel–Crafts alkylation of indoles with arylidene malonates was developed. The reaction proceeds under ambient atmosphere using a chiral bis(oxazoline)copper catalyst in a mixer mill. Under these reaction conditions nineteen 3‐substituted indole derivatives were synthesized in good to excellent yields (up to 98 %), and with good enantioselectivities (up to 91:9 e.r.) after short milling

  开发了机械化学形式的吲哚与丙二烯基丙二酸酯的不对称Michael型Friedel-Crafts烷基化反应。反应在环境气氛下使用手性双（恶唑啉）铜催化剂在混合机中进行。在这些反应条件下，经过短时间的研磨，合成了19种3取代的吲哚衍生物，收率好至极好（高达98％），对映选择性（高达91：9 er）。
• 4-Aryl or hetero-6-amino-3,4-dihydropyrid-2-one-3,5-dicarboxylic acid
  申请人：Bayer Aktiengesellschaft

  公开号：US03951990A1

  公开（公告）日：1976-04-20

  3,4-Dihydropyridones of the formula ##SPC1## Wherein R.sup.1 is hydrogen, straight or branched chain alkyl, or --COOR' wherein R' is a straight, branched or cyclic, saturated or unsaturated hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms; R.sup.2 is a straight, branched or cyclic, saturated or unsaturated hydrocarbon, aryl unsubstituted or substituted by 1 to 3 of the same or different substituents selected from the group consisting of alkyl, alkoxy, halogen, nitro, cyano, trifluoromethyl, carbalkoxy and SO.sub.n --alkyl wherein n is 0, 1 or 2, or naphthyl, quinolyl, isoquinolyl, pyridyl, pyrimidyl, thenyl, furyl or pyrryl unsubstituted or substituted by 1 or more substituents selected from the group consisting of alkyl, alkoxy and halogen; and R.sup.3 is a straight or branched chain hydrocarbon or said hydrocarbon interrupted by 1 or 2 oxygen atoms, are produced by reacting an .alpha.,.beta.-unsaturated carboxylic acid ester of the formula ##EQU1## wherein R is alkyl, alkenyl or alkynyl, and R.sup.1 and R.sup.2 are as above defined, with an amidine of the formula ##EQU2## wherein R.sup.3 is as above defined. These compounds are useful as coronary agents and as anti-hypertensive agents.

  公式为##SPC1##的3,4-二氢吡啶酮。其中R.sup.1是氢、直链或支链烷基，或--COOR'，其中R'是直链、支链或环状、饱和或不饱和碳氢化合物，或者是被1或2个氧原子打断的碳氢化合物；R.sup.2是直链、支链或环状、饱和或不饱和碳氢化合物，芳基未取代或被1到3个相同或不同的取代基取代，所述取代基选自烷基、烷氧基、卤素、硝基、氰基、三氟甲基、羰基醇酸酯和SO.sub.n--烷基，其中n为0、1或2，或者是萘基、喹啉基、异喹啉基、吡啶基、嘧啶基、噻吩基、呋喃基或吡咯基未取代或被1个或多个取代基取代，所述取代基选自烷基、烷氧基和卤素；R.sup.3是直链或支链碳氢化合物，或者是被1或2个氧原子打断的碳氢化合物，通过反应公式为##EQU1##的α，β-不饱和羧酸酯，其中R为烷基、烯基或炔基，且R.sup.1和R.sup.2如上定义，与公式为##EQU2##的脲类化合物反应制得。这些化合物可用作冠状动脉药物和降压药物。
• Condensation polymers containing methine ultraviolet radiation-absorbing
  申请人：Eastman Kodak Company

  公开号：US04845188A1

  公开（公告）日：1989-07-04

  A composition useful for molding into articles such as food containers, soft drink bottles, cured structural plastics and the like, comprising molding grade linear or unsaturated polyester or polycarbonate having reacted or copolymerized therein the residue of one or a mixture of methine reactants of the formula ##STR1## wherein R.sup.1 is an unsubstituted or substituted alkyl, cycloalkyl or aryl radical; A is an unsubstituted or substituted 1,4-phenylene radical; R.sup.2 is hydrogen or an unsubstituted or substituted alkyl, alkenyl, cycloalkyl or aryl radical; R.sup.3 is cyano, ##STR2## or an unsubstituted or substituted carbamoyl, alkanoyl, aroyl, alkylsulfonyl, arylsulfonyl, aryl or aromatic heterocyclic radicals. The methine residues are present in the polymer as an integral part of the polymer chain and absorb ultraviolet radiation in the range of about 250 to about 390 nm. The residues are non-extractable from the polymer and stable at the conditions at which the polymers are manufactured and processed.

  一种适用于塑造成食品容器、软饮料瓶、固化结构塑料等物品的组合物，包括模塑等级的线性或不饱和聚酯或聚碳酸酯，其中反应或共聚了一个或多个甲烷反应物的残留物，该甲烷反应物的化学式为##STR1##其中R.sup.1是未取代或取代的烷基、环烷基或芳基基团；A是未取代或取代的1,4-苯基基团；R.sup.2是氢或未取代或取代的烷基、烯基、环烷基或芳基基团；R.sup.3是氰基、##STR2##或未取代或取代的氨基甲酰基、烷酰基、芳酰基、烷基磺酰基、芳基磺酰基、芳基或芳香族杂环基团。该甲烷残留物以聚合物链的一部分的形式存在于聚合物中，并在约250至约390纳米的紫外线范围内吸收紫外线辐射。这些残留物从聚合物中不能被提取，并且在制造和加工聚合物时稳定。
• Condensation polymers containing methine ultraviolet radiation-absorbing residues and shaped articles produced therefrom
  申请人：EASTMAN KODAK COMPANY (a New Jersey corporation)

  公开号：EP0356350A1

  公开（公告）日：1990-02-28

  A composition useful for molding into articles such as food containers, soft drink bottles, cured structural plastics and the like, comprising molding grade linear or unsaturated polyester or polycarbonate having reacted or copolymerized therein the residue of one or a mixture of methine reactants of the formula wherein R1 is an unsubstituted or substituted alkyl, cycloalkyl or aryl radical; A is an unsubstituted or substituted 1,4-phenylene radical; R2 is hydrogen or an unsubstituted or substituted alkyl, alkenyl, cycloalkyl or aryl radical; R3 is cyano, - OR2 or an unsubstituted or substituted carbamoyl, alkanoyl, aroyl, alkylsulfonyl, arylsulfonyl, aryl or aromatic heterocyclic radicals. The methine residues are present in the polymer as an integral part of the polymer chain and absorb ultraviolet radiation in the range of 250 to 390 nm. The residues are non-extractable from the polymer and stable at the conditions at which the polymers are manufactured and processed.

  一种可用于模塑食品容器、软饮料瓶、固化结构塑料等物品的组合物，包括模塑级线性或不饱和聚酯或聚碳酸酯，其中反应或共聚有一种或多种式甲烷反应物的残留物 其中 R1 是未取代或取代的烷基、环烷基或芳基； A 是未取代或取代的 1，4-亚苯基自由基 R2 是氢或未取代或取代的烷基、烯基、环烷基或芳基； R3 是氰基、- OR2 或未取代或取代的氨基甲酰基、烷酰基、芳基、烷基磺酰基、芳基磺酰基、芳基或芳香杂环基。 残基甲烷作为聚合物链的组成部分存在于聚合物中，可吸收 250 至 390 纳米范围内的紫外线辐射。这些残基无法从聚合物中提取，并且在聚合物生产和加工条件下十分稳定。
• 10.1021/acs.orglett.4c01586
  作者：Sarkar, Biswajit、Hajra, Alakananda

  DOI：10.1021/acs.orglett.4c01586

  日期：——

  A metal-free hexafluoroisopropanol-mediated hydro-phosphorothiolation of styrenes and donor–acceptor cyclopropanes with S-hydrogen phosphorothioates in a Markovnikov fashion has been developed under ambient reaction conditions to afford a library of S-alkyl phosphorothioates. Notably, this strategy provides a simple and efficient way to produce biologically significant kitazin and iprobenfos derivatives

  已经在环境反应条件下开发了一种无金属六氟异丙醇介导的苯乙烯和供体-受体环丙烷与S-氢硫代磷酸酯以马尔可夫尼科夫方式进行的氢硫代磷酸化反应，以提供S-烷基硫代磷酸酯库。值得注意的是，该策略提供了一种简单有效的方法来生产具有生物学意义的kitazin和异丙苯磷衍生物。机理研究表明该反应通过碳阳离子中间体进行。