(R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5,5-dimethoxypentanal | 1256461-44-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5,5-dimethoxypentanal
• 英文别名: tert-butyl N-[(2R)-5,5-dimethoxy-1-oxopentan-2-yl]-N-[(2-methylpropan-2-yl)oxycarbonylamino]carbamate
• CAS: 1256461-44-5
• 化学式: C₁₇H₃₂N₂O₇
• 分子量: 376.45
• InChiKey: WBCYUNDCGSZWCL-GFCCVEGCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  103
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5,5-dimethoxypentanal 在 sodium tetrahydroborate 、 氯化铵 作用下， 以 乙醇 、 水 为溶剂， 反应 0.25h， 生成 (R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5',5'-dimethoxypentanol
  参考文献：
  名称：

  Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines

  摘要：

  Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic alpha-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.07.030
• 作为产物：
  描述：

  偶氮二甲酸二叔丁酯 、 5,5-二甲氧基戊醛 在 反式-4-叔丁氧基-L-脯氨酸 作用下， 以 二氯甲烷 为溶剂， 反应 14.0h， 以80%的产率得到(R)-2-(N,N'-di-tert-butoxycarbonylhydrazino)-5,5-dimethoxypentanal
  参考文献：
  名称：

  Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines

  摘要：

  Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic alpha-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2010.07.030

文献信息

• Organocatalytic asymmetric syntheses of functionalized tetrahydropyridazines
  作者：Delphine Kalch、Ramzi Ait Youcef、Xavier Moreau、Christine Thomassigny、Christine Greck

  DOI：10.1016/j.tetasy.2010.07.030

  日期：2010.9

  Four tetrahydropyridazines, respectively, substituted at the C-3 position with hydroxymethyl, a silyloxymethyl, a carboxylic acid, and a methyl ester have been prepared in good yields and high enantiomeric purities using organocatalytic alpha-amination of aldehydes as the key step. These compounds have then been tested as organocatalysts for the same reaction. (C) 2010 Elsevier Ltd. All rights reserved.