11Z-trideca-1,11-dien-3,5,7,9-tetrayne | 59950-58-2

• 分子结构分类: 有机化合物 - 碳氢化合物 - 不饱和烃
• 英文名称: 11Z-trideca-1,11-dien-3,5,7,9-tetrayne
• 英文别名: Tridecadien-(1,11)-tetrain-(3,5,7,9)；11Z-Trideca-1,11-dien-3,5,7,9-tetrain；trideca-1,11c-diene-3,5,7,9-tetrayne；Trideca-1,11c-dien-3,5,7,9-tetrain；(E)-1,11-Tridecadiene-3,5,7,9-tetrayne；(11Z)-trideca-1,11-dien-3,5,7,9-tetrayne
• CAS: 59950-58-2
• 化学式: C₁₃H₈
• 分子量: 164.207
• InChiKey: KBEMPFYJJCTZIG-XQRVVYSFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 氯化亚砜 、 乙醚 作用下， 生成 11Z-trideca-1,11-dien-3,5,7,9-tetrayne
  参考文献：
  名称：

  Colonization of Voice Prostheses by Albicans and Non-Albicans Candida Species

  摘要：

  AbstractObjectives The purposes of the study were to assess the colonization of tracheoesophageal voice prostheses by albicans and non‐albicans Candida species and to determine their susceptibility for three antimycotics that are frequently used for prophylaxis or treatment of oral candidiasis (i.e., miconazole, fluconazole, and nystatin).Study Design In total, 101 patients, corresponding to 170 voice prostheses, were monitored over a period of 28 months.Methods An enzymatic two‐step method was used for differentiation and presumptive identification of Candida species colonizing the voice prostheses. The identity of the isolates was confirmed by the germ‐tube test, morphological appearance on cornmeal agar with 0.5% Tween 80, sugar assimilation tests, and appearance on CHROMagar Candida (CHROMagar Co., Paris), Albicans ID (BioMérieux Vitek, Hazelwood, MO), and Fluoroplate Candida (Merck, Darmstadt, Germany). Susceptibility testing for miconazole, fluconazole, and nystatin was performed according to the microdilution method of the National Committee for Clinical Laboratory Standards.Results The predominant species isolated were Candida albicans (41.4%), Candida glabrata (33.1%), Candida krusei (15.9%), and Candida tropicalis (5.3%). A broad range of minimal inhibitory concentrations of the isolates was observed for miconazole and fluconazole. In contrast, minimal inhibitory concentration values for nystatin were narrowly distributed around 4 μg/mL for all isolates, suggesting uniform sensitivity.Conclusion Our data on the prevalence and susceptibility of yeast isolates will contribute to a rational choice of an antimycotic for prophylaxis of the early deterioration and leakage of tracheoesophageal voice prostheses.

  DOI：

  10.1097/00005537-200204000-00021

文献信息

• Colonization of Voice Prostheses by Albicans and Non-Albicans Candida Species
  作者：Tiene G. M. Bauters、Mieke Moerman、Hubert Vermeersch、Hans J. Nelis

  DOI：10.1097/00005537-200204000-00021

  日期：2002.4

  AbstractObjectives The purposes of the study were to assess the colonization of tracheoesophageal voice prostheses by albicans and non‐albicans Candida species and to determine their susceptibility for three antimycotics that are frequently used for prophylaxis or treatment of oral candidiasis (i.e., miconazole, fluconazole, and nystatin).Study Design In total, 101 patients, corresponding to 170 voice prostheses, were monitored over a period of 28 months.Methods An enzymatic two‐step method was used for differentiation and presumptive identification of Candida species colonizing the voice prostheses. The identity of the isolates was confirmed by the germ‐tube test, morphological appearance on cornmeal agar with 0.5% Tween 80, sugar assimilation tests, and appearance on CHROMagar Candida (CHROMagar Co., Paris), Albicans ID (BioMérieux Vitek, Hazelwood, MO), and Fluoroplate Candida (Merck, Darmstadt, Germany). Susceptibility testing for miconazole, fluconazole, and nystatin was performed according to the microdilution method of the National Committee for Clinical Laboratory Standards.Results The predominant species isolated were Candida albicans (41.4%), Candida glabrata (33.1%), Candida krusei (15.9%), and Candida tropicalis (5.3%). A broad range of minimal inhibitory concentrations of the isolates was observed for miconazole and fluconazole. In contrast, minimal inhibitory concentration values for nystatin were narrowly distributed around 4 μg/mL for all isolates, suggesting uniform sensitivity.Conclusion Our data on the prevalence and susceptibility of yeast isolates will contribute to a rational choice of an antimycotic for prophylaxis of the early deterioration and leakage of tracheoesophageal voice prostheses.