4-(4-isopropylbenzyl)-4',4'-dimethyl-1,4-dihydro-3H-spiro[benzo[f]quinoline-2,1'-cyclohexane]2',6'-dione | 893774-25-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-(4-isopropylbenzyl)-4',4'-dimethyl-1,4-dihydro-3H-spiro[benzo[f]quinoline-2,1'-cyclohexane]2',6'-dione
• 英文别名: 4',4'-dimethyl-4-[4-(propan-2-yl)benzyl]-3,4-dihydro-1H,2'H,6'H-spiro[benzo[f]quinoline-2,1'-cyclohexane]-2',6'-dione；5',5'-dimethyl-4-[(4-propan-2-ylphenyl)methyl]spiro[1,3-dihydrobenzo[f]quinoline-2,2'-cyclohexane]-1',3'-dione
• CAS: 893774-25-9
• 化学式: C₃₀H₃₃NO₂
• 分子量: 439.598
• InChiKey: LULBXQJDULKYTA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.4
• 重原子数：
  33
• 可旋转键数：
  3
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  37.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 N-[(4-propan-2-ylphenyl)methyl]naphthalen-2-amine 、 5,5-二甲基-1,3-环己二酮 以 乙醇 为溶剂， 反应 0.17h， 以82%的产率得到4-(4-isopropylbenzyl)-4',4'-dimethyl-1,4-dihydro-3H-spiro[benzo[f]quinoline-2,1'-cyclohexane]2',6'-dione
  参考文献：
  名称：

  Condensation of N-monosubstituted 2-naphthylamines, formaldehyde, and cyclic β-diketones. One-pot synthesis of 2,4-disubstituted derivatives of 1,2,3,4-tetrahydrobenzo[f]quinoline

  摘要：

  Various spirocyclic derivatives of 1,2,3,4-tetrahydrobenzo[f]quinoline containing substituents in the positions 2 and 4 of the ring were obtained by one-pot multicomponent condensation of available N-benzyl-2-naphthylamines, formaldehyde, and cyclic beta-diketones of cyclohexanedione series.

  DOI：

  10.1134/s1070428010090113

文献信息

• Condensation of N-monosubstituted 2-naphthylamines, formaldehyde, and cyclic β-diketones. One-pot synthesis of 2,4-disubstituted derivatives of 1,2,3,4-tetrahydrobenzo[f]quinoline
  作者：A. P. Kadutskii、N. G. Kozlov

  DOI：10.1134/s1070428010090113

  日期：2010.9

  Various spirocyclic derivatives of 1,2,3,4-tetrahydrobenzo[f]quinoline containing substituents in the positions 2 and 4 of the ring were obtained by one-pot multicomponent condensation of available N-benzyl-2-naphthylamines, formaldehyde, and cyclic beta-diketones of cyclohexanedione series.