Spiramycin III | 24916-52-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Spiramycin III
• 英文别名: [(4R,5S,6S,7R,9R,10R,11E,13E,16R)-6-[(2S,3R,4R,5S,6R)-5-[(2S,4R,5S,6S)-4,5-dihydroxy-4,6-dimethyloxan-2-yl]oxy-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-10-[(2S,5S,6R)-5-(dimethylamino)-6-methyloxan-2-yl]oxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-1-oxacyclohexadeca-11,13-dien-4-yl] propanoate
• CAS: 24916-52-7
• 化学式: C₄₆H₇₈N₂O₁₅
• 分子量: 899.1
• InChiKey: HSZLKTCKAYXVBX-HHTHJJQKSA-N

物化性质

• 熔点：
  128-131°
• 比旋光度：
  D20 -83°
• 沸点：
  923.6±65.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)
• 溶解度：
  DMSO（微溶）、甲醇（微溶、超声处理、加热）

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  63
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  201
• 氢给体数：
  3
• 氢受体数：
  17

安全信息

• 海关编码：
  2941907000

文献信息

• [EN] 2-METHYLTHIOPYRROLIDINES AND THEIR USE FOR MODULATING BACTERIAL QUORUM SENSING<br/>[FR] 2-MÉTHYLTHIOPYRROLIDINES ET LEUR UTILISATION POUR MODULER LA DÉTECTION DU QUORUM BACTÉRIEN
  申请人：FLORIDA INT UNIV BOARD TRUSTEES

  公开号：WO2012174511A1

  公开（公告）日：2012-12-20

  Compounds of Formula (I) are disclosed herein and their use in inhibiting quorum sensing in bacteria.

  本文披露了化学式（I）的化合物及其在抑制细菌中的群体感应中的应用。
• Nitrate salts of antimicrobial agents
  申请人：——

  公开号：US20030105066A1

  公开（公告）日：2003-06-05

  Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.

  抗菌药物的硝酸盐，用于制备抗菌药物，特别是抗病毒、抗真菌和抗细菌药物。
• RIBOSOME STRUCTURE AND PROTEIN SYNTHESIS INHIBITORS
  申请人：Steitz A. Thomas

  公开号：US20050036997A1

  公开（公告）日：2005-02-17

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  本发明提供了生产核糖体和核糖体亚基高分辨率晶体的方法，以及由这些方法产生的晶体。该发明还提供了核糖体亚基的高分辨率结构，无论是单独还是与蛋白质合成抑制剂结合。该发明提供了用于识别与核糖体相关的配体的方法，以及设计具有特定核糖体结合性质的配体的方法，以及可能起作用为蛋白质合成抑制剂的配体。因此，本发明的方法和组合物可用于生产专门设计用于杀灭或抑制任何目标生物生长的配体。
• [EN] NITRATE SALTS OF ANTIMICROBIAL AGENTS<br/>[FR] NITRATES D'AGENTS ANTIMICROBIENS
  申请人：NICOX SA

  公开号：WO2001054691A1

  公开（公告）日：2001-08-02

  Nitrate salts of antimicrobial agents for the preparation of antimicrobial medicaments, specifically antiviral, antifungal and antibacterial medicaments.

  硝酸盐抗微生物药剂的制备，具体包括抗病毒、抗真菌和抗菌药剂。
• Ribosome structure and protein synthesis inhibitors
  申请人：Steitz A. Thomas

  公开号：US20050272681A1

  公开（公告）日：2005-12-08

  The invention provides methods for producing high resolution crystals of ribosomes and ribosomal subunits as well as crystals produced by such methods. The invention also provides high resolution structures of ribosomal subunits either alone or in combination with protein synthesis inhibitors. The invention provides methods for identifying ribosome-related ligands and methods for designing ligands with specific ribosome-binding properties as well as ligands that may act as protein synthesis inhibitors. Thus, the methods and compositions of the invention may be used to produce ligands that are designed to specifically kill or inhibit the growth of any target organism.

  本发明提供了制备高分辨率核糖体和核糖体亚基晶体的方法，以及由这些方法产生的晶体。本发明还提供了核糖体亚基的高分辨率结构，无论是单独还是与蛋白质合成抑制剂结合。本发明提供了识别与核糖体相关的配体的方法，以及设计具有特定核糖体结合性质的配体的方法，以及可能作为蛋白质合成抑制剂的配体。因此，本发明的方法和组合物可用于生产旨在特异性杀死或抑制任何目标生物生长的配体。