1-(4-Chlorophenyl)-2-diphenylphosphanylethanone | 1262780-81-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-Chlorophenyl)-2-diphenylphosphanylethanone
• 英文别名: 1-(4-chlorophenyl)-2-diphenylphosphanylethanone
• CAS: 1262780-81-3
• 化学式: C₂₀H₁₆ClOP
• 分子量: 338.773
• InChiKey: VWFUHWCVDMNPDG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  23
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  4-氯苯乙烯 、 二苯基膦 在 (CuOTf)*toluene 、 氧气 作用下， 以 1,4-二氧六环 为溶剂， 100.0 ℃ 、607.99 kPa 条件下， 以69%的产率得到(4-chlorophenethyl)diphenylphosphine oxide
  参考文献：
  名称：

  Copper(I)-catalyzed hydrophosphination of styrenes

  摘要：

  Hydrophosphination of styrenes has been accomplished with metal salts for the first time. (CuOTf)(2).toluene complex is the catalyst of choice, but CuCl can also be used. "In-situ" EPR and NMR studies suggest Cu(I) as the catalytically active metal species, giving exclusively the anti-Markovnikov product. Phosphine oxides or beta-ketophosphine oxides can be prepared in one-pot by oxidation with molecular oxygen. (C) 2010 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2010.09.069

文献信息

• Copper(I)-catalyzed hydrophosphination of styrenes
  作者：Antonio Leyva-Pérez、Jose A. Vidal-Moya、Jose R. Cabrero-Antonino、Salem S. Al-Deyab、Saud I. Al-Resayes、Avelino Corma

  DOI：10.1016/j.jorganchem.2010.09.069

  日期：2011.1

  Hydrophosphination of styrenes has been accomplished with metal salts for the first time. (CuOTf)(2).toluene complex is the catalyst of choice, but CuCl can also be used. "In-situ" EPR and NMR studies suggest Cu(I) as the catalytically active metal species, giving exclusively the anti-Markovnikov product. Phosphine oxides or beta-ketophosphine oxides can be prepared in one-pot by oxidation with molecular oxygen. (C) 2010 Elsevier B.V. All rights reserved.