(1,3-biphenylhexahydropyrimidin-5-yl)(p-tolyl)methanone | 1359822-59-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (1,3-biphenylhexahydropyrimidin-5-yl)(p-tolyl)methanone
• 英文别名: (1,3-Diphenyl-1,3-diazinan-5-yl)-(4-methylphenyl)methanone；(1,3-diphenyl-1,3-diazinan-5-yl)-(4-methylphenyl)methanone
• CAS: 1359822-59-5
• 化学式: C₂₄H₂₄N₂O
• 分子量: 356.467
• InChiKey: XZNDPVHZWRRWNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.4
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 (E)-3-(dimethylamino)-1-p-tolylprop-2-en-1-one 、 苯胺 以 N,N-二甲基甲酰胺 为溶剂， 反应 5.0h， 以69%的产率得到(1,3-biphenylhexahydropyrimidin-5-yl)(p-tolyl)methanone
  参考文献：
  名称：

  Facile catalyst-free pseudo five-component domino reactions in the expedient synthesis of 5-aroyl-1,3-diarylhexahydropyrimidines

  摘要：

  The pseudo five-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-one, formaldehyde and aniline afford 5-aroyl-1,3-diarylhexahydropyrimidines in good yields under catalyst-free conditions. This transformation involving 4 C-N and 1 C-C bond formations in a one pot operation presumably proceeds via Michael addition-elimination-Mannich type reaction-condensative annulation-reduction sequence. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.12.097

文献信息

• Facile catalyst-free pseudo five-component domino reactions in the expedient synthesis of 5-aroyl-1,3-diarylhexahydropyrimidines
  作者：Sivasubramanian Muthusaravanan、Subbu Perumal、Abdulrahman I. Almansour

  DOI：10.1016/j.tetlet.2011.12.097

  日期：2012.2

  The pseudo five-component domino reactions of (E)-3-(dimethylamino)-1-arylprop-2-en-1-one, formaldehyde and aniline afford 5-aroyl-1,3-diarylhexahydropyrimidines in good yields under catalyst-free conditions. This transformation involving 4 C-N and 1 C-C bond formations in a one pot operation presumably proceeds via Michael addition-elimination-Mannich type reaction-condensative annulation-reduction sequence. (C) 2012 Elsevier Ltd. All rights reserved.