tert-butyl (3aSR,4SR,5SR,7RS,7aRS)-5-amino-2,2-dimethylhexahydro-4,7-epimino-1,3-benzodioxole-8-carboxylate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: tert-butyl (3aSR,4SR,5SR,7RS,7aRS)-5-amino-2,2-dimethylhexahydro-4,7-epimino-1,3-benzodioxole-8-carboxylate
• 英文别名: (+/-)-(1RS,2RS,3SR,5SR)-5-exo-amino-7-tert-butoxycarbonyl-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane；tert-butyl (1R,2R,6S,7S,8S)-8-amino-4,4-dimethyl-3,5-dioxa-10-azatricyclo[5.2.1.02,6]decane-10-carboxylate
• 化学式: C₁₄H₂₄N₂O₄
• 分子量: 284.356
• InChiKey: UYFGPROQJYLBRE-HWUMTFDVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  74
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  tert-butyl (3aSR,4SR,5SR,7RS,7aRS)-5-amino-2,2-dimethylhexahydro-4,7-epimino-1,3-benzodioxole-8-carboxylate 在 盐酸 作用下， 以 四氢呋喃 为溶剂， 反应 6.0h， 以100%的产率得到(+)-(1R,2R,3S,4S,5S)-5-exo-amino-7-azabicyclo[2.2.1]heptane-2,3-exo-diol dihydrochloride
  参考文献：
  名称：

  Synthesis of Enantiomerically Pure 1,2-Diamine Derivatives of 7-Azabicyclo[2.2.1]heptane. New Leads as Glycosidase Inhibitors and Rigid Scaffolds for the Preparation of Peptide Analogues

  摘要：

  Enantiomerically pure alcohols (-)- and (+)-7-tert-butoxycarbonyl-6-endo-p-toluenesulfonyl-7azabicyclo[2.2.1]hept-2-en-5-endo-ol ((-)-11 and (+)-11) have been obtained from the Diels-Alder adduct of N-(tert-butoxycarbonyl)pyrroel and 2-bromo-1-p-toluenesulfonylacetylene, including a resolution method. These two alcohols were converted into (+)- and (-)-5-exo-amino-7-(tertbutoxycarbonyl))-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane ((+)-18 and (-)-18) and (+)and (-)-5-endo-amino-7-(tert-butoxycarbonyl)-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane ((+)-19 and (-)-19) after adequate fanctionalization and desulfonylation steps. The corresponding conformationally constrained bicyclic 1,2-diamines (+)-4, (-)-4, (+/-)-5, (+/-)-6, (+)-7, and (-)-7 were obtained from the protected precursors 18 and 19 and evaluated as glycosidase inhibitors. Diamines (+)-4, (-)-4, (+)-6, and (-)-6 can be seen as new nonpeptide molecular scaffolds for the design of peptide analogues.

  DOI：

  10.1021/jo0301088
• 作为产物：
  描述：

  tert-butyl (1R,4S,5R,6S)-5-[(4-methylphenyl)sulfonyl]-6-({[(1R,4S)-4,7,7-trimethyl-3-oxo-2-oxabicyclo[2.2.1]hept-1-yl]carbonyl}oxy)-7-azabicyclo[2.2.1]hept-2-ene-7-carboxylate 在 palladium on activated charcoal 吡啶 、 N-morpholine oxide 、 4-二甲氨基吡啶 、 sodium amalgam 、 四氧化锇 、 叠氮基三甲基硅烷 、 四丁基氟化铵 、 氢气 、 sodium methylate 、 对甲苯磺酸 作用下， 以 四氢呋喃 、 甲醇 、 四氯化碳 、 水 、 丙酮 为溶剂， 反应 20.13h， 生成 tert-butyl (3aSR,4SR,5SR,7RS,7aRS)-5-amino-2,2-dimethylhexahydro-4,7-epimino-1,3-benzodioxole-8-carboxylate
  参考文献：
  名称：

  Synthesis of Enantiomerically Pure 1,2-Diamine Derivatives of 7-Azabicyclo[2.2.1]heptane. New Leads as Glycosidase Inhibitors and Rigid Scaffolds for the Preparation of Peptide Analogues

  摘要：

  Enantiomerically pure alcohols (-)- and (+)-7-tert-butoxycarbonyl-6-endo-p-toluenesulfonyl-7azabicyclo[2.2.1]hept-2-en-5-endo-ol ((-)-11 and (+)-11) have been obtained from the Diels-Alder adduct of N-(tert-butoxycarbonyl)pyrroel and 2-bromo-1-p-toluenesulfonylacetylene, including a resolution method. These two alcohols were converted into (+)- and (-)-5-exo-amino-7-(tertbutoxycarbonyl))-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane ((+)-18 and (-)-18) and (+)and (-)-5-endo-amino-7-(tert-butoxycarbonyl)-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane ((+)-19 and (-)-19) after adequate fanctionalization and desulfonylation steps. The corresponding conformationally constrained bicyclic 1,2-diamines (+)-4, (-)-4, (+/-)-5, (+/-)-6, (+)-7, and (-)-7 were obtained from the protected precursors 18 and 19 and evaluated as glycosidase inhibitors. Diamines (+)-4, (-)-4, (+)-6, and (-)-6 can be seen as new nonpeptide molecular scaffolds for the design of peptide analogues.

  DOI：

  10.1021/jo0301088

文献信息

• Synthesis of Enantiomerically Pure 1,2-Diamine Derivatives of 7-Azabicyclo[2.2.1]heptane. New Leads as Glycosidase Inhibitors and Rigid Scaffolds for the Preparation of Peptide Analogues
  作者：Antonio J. Moreno-Vargas、Catherine Schütz、Rosario Scopelliti、Pierre Vogel

  DOI：10.1021/jo0301088

  日期：2003.7.1

  Enantiomerically pure alcohols (-)- and (+)-7-tert-butoxycarbonyl-6-endo-p-toluenesulfonyl-7azabicyclo[2.2.1]hept-2-en-5-endo-ol ((-)-11 and (+)-11) have been obtained from the Diels-Alder adduct of N-(tert-butoxycarbonyl)pyrroel and 2-bromo-1-p-toluenesulfonylacetylene, including a resolution method. These two alcohols were converted into (+)- and (-)-5-exo-amino-7-(tertbutoxycarbonyl))-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane ((+)-18 and (-)-18) and (+)and (-)-5-endo-amino-7-(tert-butoxycarbonyl)-2,3-exo-isopropylidenedioxy-7-azabicyclo[2.2.1]heptane ((+)-19 and (-)-19) after adequate fanctionalization and desulfonylation steps. The corresponding conformationally constrained bicyclic 1,2-diamines (+)-4, (-)-4, (+/-)-5, (+/-)-6, (+)-7, and (-)-7 were obtained from the protected precursors 18 and 19 and evaluated as glycosidase inhibitors. Diamines (+)-4, (-)-4, (+)-6, and (-)-6 can be seen as new nonpeptide molecular scaffolds for the design of peptide analogues.