Multicomponent Solvent-Free Synthesis Of Benzimidazolyl Imidazo[1,2-<i>a</i>]-pyridine Under Microwave Irradiation
作者:Barnali Maiti、Kaushik Chanda、Manikandan Selvaraju、Chih-Chung Tseng、Chung-Ming Sun
DOI:10.1021/co400010y
日期:2013.6.10
A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodology facilitates the rapid generation of intricate molecular frameworks in three-dimensional fashion leading to benzinaidazole-imidazo [1,2-a] pyridines. This approach is envisioned as an environmentally benign process and a simple operation to the biological interesting compounds. The present synthetic sequence permits the introduction of three points of structural diversity to expand chemical space with high purity and excellent yields.