5-甲基-3-吲哚甲酸 | 10242-02-1

• 物质功能分类: 生物 - 细胞培养 - 添加剂
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 中文名称: 5-甲基-3-吲哚甲酸
• 中文别名: 5-甲基-1H-吲哚-3-羧酸；5-甲基吲哚-3-甲酸
• 英文名称: 5-methyl-1H-indole-3-carboxylic acid
• CAS: 10242-02-1
• 化学式: C₁₀H₉NO₂
• mdl: MFCD06203285
• 分子量: 175.187
• InChiKey: TZNAHYKFVSHGDA-UHFFFAOYSA-N

物化性质

• 熔点：
  202 °C
• 沸点：
  421.2±25.0 °C(Predicted)
• 密度：
  1.340±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  2

安全信息

• 海关编码：
  2933990090
• 危险性防范说明：
  P261,P280,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H332,H335
• 储存条件：
  2-8°C

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: 5-Methyl-1H-indole-3-carboxylic acid
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: 5-Methyl-1H-indole-3-carboxylic acid
CAS number: 10242-02-1

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels, refrigerated.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C10H9NO2
Molecular weight: 175.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide, nitrogen oxides.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

反应信息

• 作为反应物：
  描述：

  5-甲基-3-吲哚甲酸 在 氯化亚砜 作用下， 以 甲醇 为溶剂， 反应 6.0h， 生成 5-甲基吲哚-3-甲酸甲酯
  参考文献：
  名称：

  Base-Mediated Carboxylation of Unprotected Indole Derivatives with Carbon Dioxide

  摘要：

  A simple and straightforward method for the preparation of indole-3-carboxylic acids was discovered through the direct carboxylation of indoles with atmospheric pressure of carbon dioxide (CO2) under basic conditions. The key for the reaction was found to be the use of a large excess of LiO'Bu as a base to suppress the undesired decarboxylation side reaction.

  DOI：

  10.1021/ol3025082
• 作为产物：
  描述：

  5-甲基吲哚-3-甲酸甲酯 在 水 、 sodium hydroxide 作用下， 以81%的产率得到5-甲基-3-吲哚甲酸
  参考文献：
  名称：

  吲哚胺 2,3-双加氧酶 1 抑制剂的设计和合成及其作为抗肿瘤剂的应用评价

  摘要：

  吲哚胺 2,3-双加氧酶 (IDO) 1 是调节色氨酸代谢的关键酶，是阻断肿瘤免疫逃逸的重要靶点。在这项研究中，我们通过将各种片段或配体连接到吲哚或苯基咪唑支架上以提高与 IDO1 的结合，设计了四个系列的化合物作为潜在的 IDO1 抑制剂。合成了这些化合物，并评估了它们对 IDO1 和色氨酸 2,3-双加氧酶的抑制活性。还测定了化合物对两种肿瘤细胞系的细胞毒性。具有苯基咪唑支架的两种化合物（DX-03-12 和 DX-03-13）显示出有效的 IDO1 抑制，IC50 值为 0.3–0.5 μM。这两种 IDO1 抑制剂显示出低细胞毒性，这表明它们可能通过免疫调节发挥抗肿瘤作用。通过确定体内药代动力学特征和抗肿瘤功效，进一步研究了化合物 DX-03-12。药代动力学研究表明，DX-03-12 在小鼠体内具有令人满意的特性，吸收迅速、血浆清除率中等（约 36% 的肝血流量）、可接受的半衰期（约

  DOI：

  10.3390/molecules24112124

文献信息

• Copper-Mediated Cascade C–H/N–H Annulation of Indolocarboxamides with Arynes: Construction of Tetracyclic Indoloquinoline Alkaloids
  作者：Ting-Yu Zhang、Chang Liu、Chao Chen、Jian-Xin Liu、Heng-Ye Xiang、Wei Jiang、Tong-Mei Ding、Shu-Yu Zhang

  DOI：10.1021/acs.orglett.7b03580

  日期：2018.1.5

  An efficient and environmentally benign Cu-mediated method was developed for direct cascade C–H/N–H annulation to construct polyheterocyclic indoloquinoline scaffolds. This method highlights an emerging strategy for transforming inert C–H bonds into versatile functional groups in organic synthesis and provides a new versatile approach for the efficient synthesis of indolo[3,2-c] and [2,3-c]quinoline

  开发了一种高效且环境友好的铜介导的方法，用于直接级联C–H / N–H环化，以构建多杂环吲哚并喹啉支架。该方法突出了在有机合成中将惰性C–H键转变为通用官能团的新兴策略，并为有效合成吲哚[3,2- c ]和[2,3- c ]喹啉生物碱提供了新的通用方法。
• Gold(III)-Catalyzed Decarboxylative C3-Benzylation of Indole-3-carboxylic Acids with Benzylic Alcohols in Water
  作者：Hidemasa Hikawa、Fumiya Kotaki、Shoko Kikkawa、Isao Azumaya

  DOI：10.1021/acs.joc.8b02947

  日期：2019.2.15

  the indole ring in the transition state. Furthermore, comparison of initial rates in H2O and in D2O reveals an observed kinetic solvent isotope effect (KSIE = 2.7). This simple protocol, which affords the desired products with CO2 and water as the coproducts, can be achieved under mild conditions without the need for base or other additives in water.

  已经开发了金（III）催化的吲哚-3-羧酸与苯甲醇的脱羧偶联反应的策略。这种级联反应被设计为3-苄基吲哚的简单有效的合成途径，产率中等至优异（50-93％）。Hammett对原脱羧的研究给出了一个负ρ值，表明在过渡态吲哚环上会积累正电荷。此外，比较H 2 O和D 2 O中的初始速率可发现观察到的动力学溶剂同位素效应（KSIE = 2.7）。这个简单的协议，提供所需的产品与CO 2 和水作为副产物，可以在温和的条件下获得，而无需在水中添加碱或其他添加剂。
• QUINUCLIDINES FOR MODULATING ALPHA 7 ACTIVITY
  申请人：CoMentis, Inc.

  公开号：US20160009706A1

  公开（公告）日：2016-01-14

  Provided are substituted quinuclidine compounds, pharmaceutical compositions comprising such compounds, and methods of modulating α7 nicotinic acetylcholine receptors and treating neurological disorders using such compounds.

  提供了替代性的喹诺啡啶化合物，包括这些化合物的药物组合物，以及使用这些化合物调节α7烟碱乙酰胆碱受体和治疗神经系统疾病的方法。
• NOVEL INDOL CARBOXYLIC ACID BISPYRIDYL CARBOXAMIDE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, PREPARATION METHOD AND COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：SEONG Churlmin

  公开号：US20090258876A1

  公开（公告）日：2009-10-15

  Disclosed herein are a new indole carboxylic acid bispyridyl carboxamide derivative, a preparation method thereof, and a composition for prevention or treatment of obesity, urinary disorders, and CNS disorders, containing the same as an active ingredient. Because the indole carboxylic acid bispyridyl carboxamide derivatives according to the present invention have high affinity for 5-HT 2c receptors, act selectively on the 5-HT 2c receptors, the derivatives rarely have adverse effects caused by other receptors. Because the derivatives effectively inhibit serotonin activity, they may be useful for treatment or prevention of obesity; urinary disorders such as urinary incontinence, premature ejaculation, erectile dysfunction, and prostatic hyperplasia; CNS disorders such as depression, anxiety, concern, panic disorder, epilepsy, obsessive-compulsive disorder, migraine, sleep disorder, withdrawal from drug abuse, Alzheimer's disease, and schizophrenia, associated with 5-HT 2c receptors.

  本公开涉及一种新的吲哚羧酸双吡啶羧酰胺衍生物，其制备方法，以及包含该衍生物作为活性成分的用于预防或治疗肥胖、泌尿系统疾病和中枢神经系统疾病的组合物。根据本发明的吲哚羧酸双吡啶羧酰胺衍生物具有高亲和力5-HT2c受体，对5-HT2c受体选择性作用，这些衍生物很少出现由其他受体引起的不良反应。由于这些衍生物有效抑制5-羟色胺活性，它们可能对治疗或预防肥胖；泌尿系统疾病，如尿失禁、早泄、勃起功能障碍和前列腺增生；以及与5-HT2c受体相关的中枢神经系统疾病，如抑郁症、焦虑症、关注症、恐慌症、癫痫、强迫症、偏头痛、睡眠障碍、戒毒、阿尔茨海默病和精神分裂症可能有用。
• Vinyl Sulfone-Based Inhibitors of Nonstructural Protein 2 Block the Replication of Venezuelan Equine Encephalitis Virus
  作者：Huaisheng Zhang、Moeshia Harmon、Sheli R. Radoshitzky、Veronica Soloveva、Christopher D. Kane、Allen J. Duplantier、Ifedayo Victor Ogungbe

  DOI：10.1021/acsmedchemlett.0c00215

  日期：2020.11.12

  an acrylate and vinyl sulfone-based chemical series was investigated as promising starting scaffolds against VEEV and as inhibitors of the cysteine protease domain of VEEV’s nonstructural protein 2 (nsP2). Primary screen and dose response studies were performed to evaluate the potency and cytotoxicity of the compounds. The results provide structural insights into a new class of potent nonpeptidic covalent

  委内瑞拉马脑炎病毒 (VEEV) 等虫媒病毒引起的新发传染病对公共卫生系统构成严重威胁。制定针对新发传染病的医学对策至关重要。在这项工作中，基于丙烯酸酯和乙烯基砜的化学系列被研究为有前途的 VEEV 起始支架和作为 VEEV 非结构蛋白 2 (nsP2) 半胱氨酸蛋白酶结构域的抑制剂。进行初步筛选和剂量反应研究以评估化合物的效力和细胞毒性。结果提供了对由化合物11 (VEEV TrD, EC 50= 2.4 μM (HeLa), 1.6 μM (Vero E6))。这些结果可能有助于将化合物进化为选择性和广谱的抗甲病毒药物先导药物。