6-acetamido-7-chlorophthalazine-5,8-dione | 735307-89-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-acetamido-7-chlorophthalazine-5,8-dione
• 英文别名: N-(7-chloro-5,8-dioxophthalazin-6-yl)acetamide
• CAS: 735307-89-8
• 化学式: C₁₀H₆ClN₃O₃
• 分子量: 251.629
• InChiKey: SSLZEDVUETUZOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  89
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-acetamido-7-chlorophthalazine-5,8-dione 在 sodium hydroxide 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 1.0h， 生成 3-butyl-2-methylimidazo[4,5-g]phthalazine-4,9-dione
  参考文献：
  名称：

  Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives

  摘要：

  A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5.8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.04.014
• 作为产物：
  描述：

  6,7-二氯酞嗪-5,8-二酮 在 sodium tetrahydroborate 、 sodium azide 、 硫酸 、 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 5.5h， 生成 6-acetamido-7-chlorophthalazine-5,8-dione
  参考文献：
  名称：

  Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives

  摘要：

  A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5.8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2004.04.014

文献信息

• US7160884B2
  申请人：——

  公开号：US7160884B2

  公开（公告）日：2007-01-09
• Synthesis and cytotoxicity of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives
  作者：Jin Sung Kim、Hyun-Jung Lee、Myung-Eun Suh、Hea-Young Park Choo、Sang Kook Lee、Hyen Joo Park、Choonmi Kim、Sang Woo Park、Chong-Ock Lee

  DOI：10.1016/j.bmc.2004.04.014

  日期：2004.7

  A series of 1-substituted 2-methyl-1H-imidazo[4,5-g]phthalazine-4,9-dione derivatives 8 was synthesized from 6,7-dichlorophthalazine-5.8-dione 5 and evaluated for in vitro cytotoxicity against several human tumor cell lines. Most of the tested compounds showed potential cytotoxic activity considerably higher than that of the reference compounds, ellipticine and doxorubicin. (C) 2004 Elsevier Ltd. All rights reserved.