(2E,4Z)-2-methyl-hexa-2,4-dienal | 54716-16-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (2E,4Z)-2-methyl-hexa-2,4-dienal
• 英文别名: (2E,4Z)-2-methylhexa-2,4-dienal
• CAS: 54716-16-4
• 化学式: C₇H₁₀O
• 分子量: 110.156
• InChiKey: USLLTQZDXQTRIR-QVXLNCAUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  8
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-丙烯基溴化镁 、 2-甲基-3-乙氧基丙烯醛 在 氯化铵 作用下， 生成 (2E,4Z)-2-methyl-hexa-2,4-dienal 、 (E,E)-2-methylhexa-2,4-dienal
  参考文献：
  名称：

  Spangler, Charles W.; Tan, Robin P. K.; Gibson, Robert S., Synthetic Communications, 1985, vol. 15, # 5, p. 371 - 376

  摘要：

  DOI：

文献信息

• [EN] BICYCLIC HETEROARYL INDOLE ANALOGUES USEFUL AS ROR GAMMA MODULATORS<br/>[FR] ANALOGUES DE L'INDOLE HÉTEROARYLE BICYCLIQUE UTILES EN TANT QUE MODULATEURS DE GAMMA ROR
  申请人：GLENMARK PHARMACEUTICALS SA

  公开号：WO2015087234A1

  公开（公告）日：2015-06-18

  The present disclosure is directed to compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein X, X1, M, R2, R3, R4, R5, m, n, and p are as defined herein, which are active as modulators of retinoid-related orphan receptor gamma t (RORγt). These compounds prevent, inhibit, or suppress the action of RORγt and are therefore useful in the treatment of RORγt mediated diseases, disorders, syndromes or conditions such as, e.g., pain, inflammation, COPD, asthma, rheumatoid arthritis, colitis, multiple sclerosis, neurodegenerative diseases and cancer.

  本公开涉及式(I)的化合物及其药用盐，其中X、X1、M、R2、R3、R4、R5、m、n和p如本文所定义，这些化合物作为视黄醇相关孤儿受体γt（RORγt）调节剂具有活性。这些化合物可以预防、抑制或抑制RORγt的作用，因此在治疗RORγt介导的疾病、疾病、综合症或病况中具有用处，例如疼痛、炎症、慢性阻塞性肺病（COPD）、哮喘、类风湿关节炎、结肠炎、多发性硬化症、神经退行性疾病和癌症。
• LAUNDRY CARE COMPOSITIONS, METHODS, AND TEST KITS FOR DETERMINING AUTHENTICITY
  申请人：The Procter & Gamble Company

  公开号：US20190112551A1

  公开（公告）日：2019-04-18

  The present disclosure provides a laundry care composition having at least one laundry care ingredient and at least one leuco composition conforming to Formula (I): Ar 1 Ar 2 Ar 3 CH  (I) wherein Ar 2 and Ar 3 are independently a carbocyclic aryl or heteroaryl, and Ar 1 is selected from the group consisting of: unsubstituted phenyl, electron deficient carbocyclic aryl, and heteroaryl. The present disclosure also provides a method of determining an authentic laundry care composition and test kits for detecting authentic laundry care compositions.

  本公开提供一种洗涤护理组合物，其中至少包含一种洗涤护理成分和至少一种符合以下式（I）的还原组合物：Ar1Ar2Ar3CH  （I）其中Ar2和Ar3分别是一个碳环芳基或杂环芳基，Ar1选自以下组：未取代的苯基、电子亏缺的碳环芳基和杂环芳基。本公开还提供了一种确定真正洗涤护理组合物的方法和用于检测真正洗涤护理组合物的测试套装。
• Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
  申请人：Bristol-Myers Squibb Company

  公开号：EP2002837A1

  公开（公告）日：2008-12-17

  Novel biphenyl sulfonamide compounds which are combined angiotensin and endothelin receptor antagonists are claimed along with methods of using such compounds in the treatment of conditions such as hypertension and other diseases, as well as pharmaceutical compositions containing such compounds.

  本发明公开了新型联苯磺酰胺化合物（血管紧张素和内皮素受体联合拮抗剂），以及使用此类化合物治疗高血压和其他疾病的方法和含有此类化合物的药物组合物。
• Luminescent 1-Hydroxy-2-Pyridinone Chelates of Lanthanides
  申请人：The Regents of The University of California

  公开号：EP2511266A1

  公开（公告）日：2012-10-17

  The present invention provides luminescent complexes between a lanthanide ion and an organic ligand which contains 1,2-hydroxypyridinone units. The complexes of the invention are stable in aqueous solutions and are useful as molecular probes, for example in medical diagnostics and bioanalytical assay systems. The invention also provides methods of using the complexes of the invention.

  本发明提供了镧系元素离子与含有 1,2-羟基吡啶酮单元的有机配体之间的发光复合物。本发明的配合物在水溶液中稳定，可用作分子探针，例如用于医疗诊断和生物分析检测系统。本发明还提供了使用本发明复合物的方法。
• PYRROLE DERIVATIVE
  申请人：Dainippon Sumitomo Pharma Co., Ltd.

  公开号：EP1386913B1

  公开（公告）日：2008-07-16