1-(4-(E-3,7-dimethylocta-2,6-dienyloxy)-2.6-dihydroxylphenyl)-2-methylpropan-1-one | 71539-65-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(E-3,7-dimethylocta-2,6-dienyloxy)-2.6-dihydroxylphenyl)-2-methylpropan-1-one
• 英文别名: 1-[4-[(2E)-3,7-dimethylocta-2,6-dienoxy]-2,6-dihydroxyphenyl]-2-methylpropan-1-one
• CAS: 71539-65-6
• 化学式: C₂₀H₂₈O₄
• 分子量: 332.44
• InChiKey: TUADKQOMMLPDOK-OQLLNIDSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  24
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  香叶基焦磷酸铵盐 、 phlorisobutyrophenone 在 Aspergillus terreus aromatic prenyltransferase 、 calcium chloride 作用下， 以 二甲基亚砜 、 甘油 为溶剂， 反应 2.0h， 以32.85%的产率得到3-geranyl-1-(2'-methylpropanoyl)phloroglucinol
  参考文献：
  名称：

  gem-Diprenylation of Acylphloroglucinols by a Fungal Prenyltransferase of the Dimethylallyltryptophan Synthase Superfamily

  摘要：

  Aspergillus terreus aromatic prenyltransferase (AtaPT) catalyzes predominantly C-monoprenylation of acylphloroglucinols in the presence of different prenyl diphosphates. With dimethylallyl diphosphate (DMAPP) as prenyl donor, gem-diprenylated products 1D3, 2D3, and 3D3 were also detected. High conversion of 1D1 to 1D3, 2D1 to 2D3, and 3D1 to 3D3 was demonstrated by incubation with AtaPT and DMAPP. The first example of gem-diprenylation by a member of the dimethylallyltryptophan synthase superfamily is provided.

  DOI：

  10.1021/acs.orglett.6b03594

文献信息

• <i>gem</i>-Diprenylation of Acylphloroglucinols by a Fungal Prenyltransferase of the Dimethylallyltryptophan Synthase Superfamily
  作者：Kang Zhou、Carsten Wunsch、Jungui Dai、Shu-Ming Li

  DOI：10.1021/acs.orglett.6b03594

  日期：2017.1.20

  Aspergillus terreus aromatic prenyltransferase (AtaPT) catalyzes predominantly C-monoprenylation of acylphloroglucinols in the presence of different prenyl diphosphates. With dimethylallyl diphosphate (DMAPP) as prenyl donor, gem-diprenylated products 1D3, 2D3, and 3D3 were also detected. High conversion of 1D1 to 1D3, 2D1 to 2D3, and 3D1 to 3D3 was demonstrated by incubation with AtaPT and DMAPP. The first example of gem-diprenylation by a member of the dimethylallyltryptophan synthase superfamily is provided.