4-ethyl-1,3-cyclopentanedione | 57157-03-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-ethyl-1,3-cyclopentanedione
• 英文别名: 4-Aethyl-1,3-cyclopentandion；4-ethylcyclopentane-1,3-dione
• CAS: 57157-03-6
• 化学式: C₇H₁₀O₂
• 分子量: 126.155
• InChiKey: GXLHXLFBLQXKMP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  cyclopentane-1,3-dione dimethylhydrazone 在 盐酸 、 正丁基锂 、 四甲基乙二胺 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 2.0h， 生成 4-ethyl-1,3-cyclopentanedione
  参考文献：
  名称：

  经由其单二甲基hydr将环状1.3-二酮的二价阴离子进行区域选择性烷基化。C-4取代的环状1.3-二酮的合成

  摘要：

  将环状的1.3-二酮转化为相应的单二甲基azo，其可以在C-4处通过带有各种烷基卤化物的二价阴离子在区域C-4上进行区域选择性烷基化。

  DOI：

  10.1016/s0040-4039(00)99560-1

文献信息

• Pyrazolopyridine cycloalkanone derivatives
  申请人：ICI AMERICAS INC.

  公开号：EP0141608A2

  公开（公告）日：1985-05-15

  Novel tetrahydropyrazolo-[3,4-b]quinolinones, cyclo- benta[b]pyrazolo-[4,3-e]pyridinones and cyclohepta[b]-pyraz- olo-[4,3-e]pyridinones are disclosed useful as anxiolytics hav- ng reduced side effects are disclosed, including methods of preparation, pharmaceutical compositions containing them and intermediates used in their preparation.

  公开了新型四氢吡唑并-[3,4-b]喹啉酮类、环庚并[b]吡唑并-[4,3-e]吡啶酮类和环庚并[b]吡唑并-[4,3-e]吡啶酮类抗焦虑药物，包括制备方法、含有这些药物的药物组合物以及用于制备这些药物的中间体。
• DEMIR, AYHAN S.;ENDERS, DIETER, TETRAHEDRON LETT., 30,(1989) N3, C. 1705-1708
  作者：DEMIR, AYHAN S.、ENDERS, DIETER

  DOI：——

  日期：——
• BILE ACID ANALOGS AS FXR/TGR5 AGONISTS AND METHODS OF USE THEREOF
  申请人：Enanta Pharmaceuticals, Inc.

  公开号：US20160145296A1

  公开（公告）日：2016-05-26

  The present invention relates to compounds of Formula (IA) and Formula (IB), and pharmaceutically acceptable salts thereof, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 and m are as defined herein, pharmaceutical compositions comprising these compounds and methods of use of these compounds for treating a TGR5 mediated disease or condition.
• LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY DEVICE INCLUDING THE SAME, AND METHOD OF MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE
  申请人：SAMSUNG DISPLAY CO., LTD.

  公开号：US20170210994A1

  公开（公告）日：2017-07-27

  A liquid crystal composition including: a liquid crystal compound and a liquid crystal aligning agent including at least one compound represented by Formula 1: wherein in the Formula 1, X—*, *-L 1 -*, *-L 2 -*, *-L 3 -*, *—C—*, *—R—*, *—Y, n 1 , n 2 , and m are the same as defined in the specification.
• MULTIFUNCTIONALIZED POLYETHYLENE GLYCOL DERIVATIVE AND PREPARATION METHOD THEREFOR
  申请人：XIAMEN SINOPEG BIOTECH CO., LTD.

  公开号：US20170312363A1

  公开（公告）日：2017-11-02

  Disclosed are a multifunctionalized polyethylene glycol derivative and a preparation method therefor. The derivative has an H-shaped structure as represented by formula (1) and comprises one linear core LPEG and four PEG branch chains, where n 1 , n 2 , n 3 , and n 4 respectively are the degrees of polymerization of the branch chains, U 1 and U 2 are trivalent branching groups connecting the core LPEG to two of the PEG branch chains, F 1 and F 2 contain a functional group or a protected form R 01 thereof and may or may not contain a branched group G, correspondingly, the number of R 01 is one or more, F 1 and F 2 are either identical or different, any one linking group in the molecule or any linking group formed with an adjacent heteroatom group can either remain stable or be degraded, and any one PEG segment in the molecule is discretely polydispersed or monodispersed. The multifunctional polyethylene glycol is flexible and diverse in terms of branch structures and the lengths of branching arms, has various parameters and performance indicators that are adjustable and easy to control, and has a broad applicability.