4-[6-(4-Hydroxy-3,5-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2,6-bis(hydroxymethyl)phenol

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 呋喃类木脂素
• 英文名称: 4-[6-(4-Hydroxy-3,5-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2,6-bis(hydroxymethyl)phenol
• 英文别名: 4-[6-(4-hydroxy-3,5-dimethoxyphenyl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-3-yl]-2,6-bis(hydroxymethyl)phenol
• 化学式: C₂₂H₂₆O₈
• 分子量: 418.4
• InChiKey: KULNWZFKCSMLGE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  8

文献信息

• COMPOSITION FOR PREVENTING OR TREATING HEART DISEASE
  申请人：AMOREPACIFIC CORPORATION

  公开号：US20150283110A1

  公开（公告）日：2015-10-08

  The present invention relates to a composition for preventing or treating heart disease, and more particularly, to a composition for preventing or treating heart disease, comprising (+)-syringaresinol. Specifically, (+)-syringaresinol as an active ingredient may exhibit excellent effect of preventing or improving heart disease by promoting SIRT1 expression and suppressing death of cardiomyocytes induced by reactive oxygen species. Accordingly, the composition according to the present disclosure may be used to prevent, improve or treat heart diseases including cardiovascular diseases.

  本发明涉及一种用于预防或治疗心脏疾病的组合物，更具体地，涉及一种包含(+)-丁香酚的预防或治疗心脏疾病的组合物。具体而言，(+)-丁香酚作为活性成分，可以通过促进SIRT1表达和抑制由活性氧引起的心肌细胞死亡，展现出预防或改善心脏疾病的卓越效果。因此，根据本公开的组合物可用于预防、改善或治疗包括心血管疾病在内的心脏疾病。
• COMPOSITION COMPRISING SYRINGARESINOL FOR IMPROVING THE SKIN
  申请人：AMOREPACIFIC CORPORATION

  公开号：US20150290105A1

  公开（公告）日：2015-10-15

  The present invention relates to a composition for improving the skin, which comprises the compound of chemical formula 1, the derivatives thereof, or the pharmaceutically acceptable salts thereof as active ingredients.

  本发明涉及一种用于改善皮肤的组合物，其包括化学式1的化合物，其衍生物或其药学上可接受的盐作为活性成分。
• SIRT 1 activator including syringaresinol
  申请人：AMOREPACIFIC CORPORATION

  公开号：US10022351B2

  公开（公告）日：2018-07-17

  The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.

  本发明涉及一种式 1 的化合物，以及一种 SIRT 1 激活剂，包括作为活性成分的其 衍生物或其药学上可接受的盐。本发明还涉及一种包括 SIRT 1 激活剂的组合物，用于解毒、改善代谢紊乱、预防或改善眼部疾病或预防或改善免疫疾病。
• COMPOSITION FOR INHIBITING VASCULAR AGING COMPRISING SYRINGARESINOL
  申请人：AMOREPACIFIC CORPORATION

  公开号：US20140248381A1

  公开（公告）日：2014-09-04

  The present invention discloses a composition for inhibiting vascular aging comprising a compound of Chemical formula 1, a derivative thereof or a pharmaceutically acceptable salt thereof as an active ingredient.
• SIRT 1 ACTIVATOR INCLUDING SYRINGARESINOL
  申请人：AMOREPACIFIC CORPORATION

  公开号：US20140371307A1

  公开（公告）日：2014-12-18

  The present invention relates to a compound of Formula 1, and an SIRT 1 activator including, as an active ingredient, derivatives thereof or pharmaceutically acceptable salts thereof. The present invention also relates to a composition including the SIRT 1 activator for detoxification, for the improvement of metabolic disorders, for the prevention or improvement of eye diseases, or the prevention or improvement of immune diseases.