(3aR,5S,6R,6aR,E)-6-(benzylideneaminoxy)-N-isobutyl-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxole-5-carboxamide | 1087203-97-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,5S,6R,6aR,E)-6-(benzylideneaminoxy)-N-isobutyl-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxole-5-carboxamide
• 英文别名: (3aR,5S,6R,6aR)-6-[(E)-benzylideneamino]oxy-2,2-dimethyl-N-(2-methylpropyl)-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole-5-carboxamide
• CAS: 1087203-97-1
• 化学式: C₁₉H₂₆N₂O₅
• 分子量: 362.426
• InChiKey: XZKFDOGXYZJNRS-UIIULVDUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  78.4
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  (3aR,5S,6R,6aR)-6-(aminooxy)-N-isobutyl-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-carboxamide 、 苯甲醛 以 二氯甲烷 为溶剂， 反应 12.0h， 以77.2%的产率得到(3aR,5S,6R,6aR,E)-6-(benzylideneaminoxy)-N-isobutyl-2,2-dimethyl-tetrahydrofuro[2,3-d][1,3]dioxole-5-carboxamide
  参考文献：
  名称：

  β-Sugar Aminoxy Peptides As Rigid Secondary Structural Scaffolds

  摘要：

  Short homo-oligomers of a new building block, cis-beta(2,3)-furanoid sugar aminoxy acid. are designed, characterized. and found to exhibit rigid ribbon-like secondary structures composed of 5/7 bifurcated intramolecular hydrogen bonds.

  DOI：

  10.1021/jo801810z

文献信息

• β-Sugar Aminoxy Peptides As Rigid Secondary Structural Scaffolds
  作者：Srivari Chandrasekhar、Chennamaneni Lohitha Rao、Marepally Srinivasa Reddy、Ganti Dattatreya Sharma、Marelli Udaya Kiran、Police Naresh、Gunturu Krishna Chaitanya、Kotamarthi Bhanuprakash、Bharatam Jagadeesh

  DOI：10.1021/jo801810z

  日期：2008.12.5

  Short homo-oligomers of a new building block, cis-beta(2,3)-furanoid sugar aminoxy acid. are designed, characterized. and found to exhibit rigid ribbon-like secondary structures composed of 5/7 bifurcated intramolecular hydrogen bonds.