L-Threonine, N-(1-L-lysyl-D-prolyl)- | 117027-34-6

• 物质功能分类: 生物化工 - 多肽
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Threonine, N-(1-L-lysyl-D-prolyl)-
• 英文别名: (2S,3R)-2-[[(2R)-1-[(2S)-2,6-diaminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxybutanoic acid
• CAS: 117027-34-6
• 化学式: C₁₅H₂₈N₄O₅
• 分子量: 344.41
• InChiKey: LOGFVTREOLYCPF-KXNHARMFSA-N

物化性质

• 溶解度：
  H2O：10 mg/mL，澄清，无色

计算性质

• 辛醇/水分配系数(LogP)：
  -5.1
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.8
• 拓扑面积：
  159
• 氢给体数：
  5
• 氢受体数：
  7

安全信息

• WGK Germany：
  3
• 安全说明：
  S22,S24/25

文献信息

• Storage stable lyophilized tripeptide formulations
  申请人：Dr. August Wolff Gmbh & Co. KG Arzneimittel

  公开号：US10383911B2

  公开（公告）日：2019-08-20

  The invention relates to Lysyl-Prolyl-Threonine lyophilized formulations, in particular to L-Lysyl-D-Prolyl-L-Threonine lyophilized formulations, that are stable in storage, and to a process for preparing the lyophilized formulations. Moreover, the invention relates to pharmaceutical and cosmetic compositions comprising the lyophilized formulations, that are used in the therapeutic and/or prophylactic treatment, diagnosis and/or therapy of pain-related diseases, pruritus-related diseases, inflammatory diseases, and/or other diseases in a mammal.

  本发明涉及贮存稳定的赖氨酰-脯氨酰-苏氨酸冻干制剂，特别是L-赖氨酰-D-脯氨酰-L-苏氨酸冻干制剂，以及制备冻干制剂的工艺。此外，本发明还涉及包含该冻干制剂的药物和化妆品组合物，该组合物可用于哺乳动物疼痛相关疾病、瘙痒相关疾病、炎症性疾病和/或其他疾病的治疗和/或预防性治疗、诊断和/或疗法。
• STORAGE STABLE LYOPHILIZED TRIPEPTIDE FORMULATIONS
  申请人：Dr. August Wolff GmbH & Co. KG Arzneimittel

  公开号：EP3065756B1

  公开（公告）日：2019-02-20
• [EN] STORAGE STABLE LYOPHILIZED TRIPEPTIDE FORMULATIONS<br/>[FR] FORMULATIONS DE TRIPEPTIDES LYOPHILISÉES STABLES EN STOCKAGE
  申请人：WOLFF AUGUST GMBH & CO KG ARZNEIMITTEL DR

  公开号：WO2015067493A1

  公开（公告）日：2015-05-14

  The invention relates to Lysyl-Prolyl- Threonine lyophilized formulations, in particular to L-Lysyl-D-Prolyl-L-Threonine lyophilized formulations, that are stable in storage, and to a process for preparing the lyophilized formulations. Moreover, the invention relates to pharmaceutical and cosmetic compositions comprising the lyophilized formulations, that are used in the therapeutic and/or prophylactic treatment, diagnosis and/or therapy of pain-related diseases, pruritus-related diseases, inflammatory diseases, and/or other diseases in a mammal.