6,6,7,7,8,8,9,9,10,10,11,11,11-十三氟-4-碘-1-十一烷醇 | 132665-00-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 中文名称: 6,6,7,7,8,8,9,9,10,10,11,11,11-十三氟-4-碘-1-十一烷醇
• 英文名称: 5-(F-hexyl)-4-iodopentanol
• 英文别名: 6,6,7,7,8,8,9,9,10,10,11,11,11-Tridecafluoro-4-iodoundecan-1-ol
• CAS: 132665-00-0
• 化学式: C₁₁H₁₀F₁₃IO
• 分子量: 532.084
• InChiKey: FPLJNGUIASXYLD-UHFFFAOYSA-N

物化性质

• 沸点：
  267.7±40.0 °C(Predicted)
• 密度：
  1.785±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  26
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  14

反应信息

• 作为反应物：
  描述：

  6,6,7,7,8,8,9,9,10,10,11,11,11-十三氟-4-碘-1-十一烷醇 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 2-<(F-hexyl)methyl>tetrahydrofuran
  参考文献：
  名称：

  Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives

  摘要：

  Fluoroalkylation of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 was carried out at 5-10 degrees C in aqueous acetonitrile affording corresponding adducts, which were converted to fluoroalkyl tetrahydrofurans by heating in DMF or acetonitrile, providing a convenient method for the synthesis of fluorine-containing tetrahydrofuran derivatives. (c) 2007 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2007.05.013
• 作为产物：
  描述：

  2-氯甲基四氢呋喃 在 偶氮二异丁腈 、 sodium 作用下， 以 乙醚 为溶剂， 反应 2.0h， 生成 6,6,7,7,8,8,9,9,10,10,11,11,11-十三氟-4-碘-1-十一烷醇
  参考文献：
  名称：

  Synthèse d'acides ω perfluoroalkylalcanoı̈ques et d'ω perfluoroalkylalcanols

  摘要：

  DOI：

  10.1016/s0022-1139(99)00078-0

文献信息

• Addition of perfluoroalkyl iodides to 4-pentenol and its derivatives: one-pot preparation of 2-[(F-alkyl)methyl]tetrahydrofurans
  作者：J. Greiner、A. Milius、J.G. Riess

  DOI：10.1016/s0022-1139(00)81175-6

  日期：1992.3

  Depending on the nature of the alkaline medium, the radical addition of perfluoroalkyl iodides to 4-pentenol gives a mixture of 5-(F-alkyl)-4-pentenol and 2-[(F-alkyl)- methyl]tetrahydrofuran, or the latter alone.

  根据碱性介质的性质，将全氟烷基碘化物自由基加成到4-戊烯醇中可得到5-（F-烷基）-4-戊烯醇和2-[（F-烷基）-甲基]四氢呋喃的混合物，或后者一个人。
• Lactone Synthesis Based on Atom Transfer Carbonylation
  作者：Sergio Kreimerman、Ilhyong Ryu、Satoshi Minakata、Mitsuo Komatsu

  DOI：10.1021/ol9913441

  日期：2000.2.1

  [GRAPHICS]Five- to seven-membered lactones were prepared from omega-hydroxyalkyl iodides and CO by atom transfer carbonylation without the need for transition metal catalysts, The reaction proceeds via a hybrid radical/ionic mechanism in which the intramolecular alcoholysis of an omega-hydroxyacyl iodide, arising from atom transfer carbonylation, leads to the lactone.
• Synthèse d'acides ω perfluoroalkylalcanoı̈ques et d'ω perfluoroalkylalcanols
  作者：D. Tra Anh、H. Blancou、A. Commeyras

  DOI：10.1016/s0022-1139(99)00078-0

  日期：1999.7
• Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives
  作者：Xueyan Yang、Zhonghua Wang、Yaoping Zhu、Xiang Fang、Xianjin Yang、Fanhong Wu、Yongjia Shen

  DOI：10.1016/j.jfluchem.2007.05.013

  日期：2007.9

  Fluoroalkylation of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 was carried out at 5-10 degrees C in aqueous acetonitrile affording corresponding adducts, which were converted to fluoroalkyl tetrahydrofurans by heating in DMF or acetonitrile, providing a convenient method for the synthesis of fluorine-containing tetrahydrofuran derivatives. (c) 2007 Published by Elsevier B.V.