2-<(F-hexyl)methyl>tetrahydrofuran | 135131-52-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: 2-<(F-hexyl)methyl>tetrahydrofuran
• 英文别名: 2-(2,2,3,3,4,4,5,5,6,6,7,7,7-tridecafluoroheptyl)-tetrahydrofuran；2-(2,2,3,3,4,4,5,5,6,6,7,7,7-Tridecafluoroheptyl)oxolane
• CAS: 135131-52-1
• 化学式: C₁₁H₉F₁₃O
• 分子量: 404.171
• InChiKey: MXEXFOFBYUASFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  14

反应信息

• 作为产物：
  描述：

  6,6,7,7,8,8,9,9,10,10,11,11,11-十三氟-4-碘-1-十一烷醇 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.0h， 生成 2-<(F-hexyl)methyl>tetrahydrofuran
  参考文献：
  名称：

  Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives

  摘要：

  Fluoroalkylation of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 was carried out at 5-10 degrees C in aqueous acetonitrile affording corresponding adducts, which were converted to fluoroalkyl tetrahydrofurans by heating in DMF or acetonitrile, providing a convenient method for the synthesis of fluorine-containing tetrahydrofuran derivatives. (c) 2007 Published by Elsevier B.V.

  DOI：

  10.1016/j.jfluchem.2007.05.013

文献信息

• Addition of perfluoroalkyl iodides to 4-pentenol and its derivatives: one-pot preparation of 2-[(F-alkyl)methyl]tetrahydrofurans
  作者：J. Greiner、A. Milius、J.G. Riess

  DOI：10.1016/s0022-1139(00)81175-6

  日期：1992.3

  Depending on the nature of the alkaline medium, the radical addition of perfluoroalkyl iodides to 4-pentenol gives a mixture of 5-(F-alkyl)-4-pentenol and 2-[(F-alkyl)- methyl]tetrahydrofuran, or the latter alone.

  根据碱性介质的性质，将全氟烷基碘化物自由基加成到4-戊烯醇中可得到5-（F-烷基）-4-戊烯醇和2-[（F-烷基）-甲基]四氢呋喃的混合物，或后者一个人。
• MILIUS, ALAIN;GREINER, JACQUES;RIESS, JEAN G., NEW J. CHEM., 15,(1991) N, C. 337-344
  作者：MILIUS, ALAIN、GREINER, JACQUES、RIESS, JEAN G.

  DOI：——

  日期：——
• Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives
  作者：Xueyan Yang、Zhonghua Wang、Yaoping Zhu、Xiang Fang、Xianjin Yang、Fanhong Wu、Yongjia Shen

  DOI：10.1016/j.jfluchem.2007.05.013

  日期：2007.9

  Fluoroalkylation of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 was carried out at 5-10 degrees C in aqueous acetonitrile affording corresponding adducts, which were converted to fluoroalkyl tetrahydrofurans by heating in DMF or acetonitrile, providing a convenient method for the synthesis of fluorine-containing tetrahydrofuran derivatives. (c) 2007 Published by Elsevier B.V.