6,9-二[(2-氨基乙基)氨基]苯并[g]喹啉-5,10-二酮 | 150629-26-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 中文名称: 6,9-二[(2-氨基乙基)氨基]苯并[g]喹啉-5,10-二酮
• 英文名称: 6,9-bis<(2-aminoethyl)amino>benzoquinoline-5,10-dione
• 英文别名: 6,9-bis[(2-amino)ethyl]amino-benzo[g]isoquinoline-5,10-dione；5,8-Bis(2-aminoethylamino)-1-azaanthracene-9,10-dione；6,9-bis(2-aminoethylamino)benzo[g]quinoline-5,10-dione
• CAS: 150629-26-8
• 化学式: C₁₇H₁₉N₅O₂
• 分子量: 325.37
• InChiKey: LERLSYZHEFMEBV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  123
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  2,3-吡啶二羧酸酐 在 三氯化铝 、 硫酸 作用下， 以 氯仿 为溶剂， 反应 166.5h， 生成 6,9-二[(2-氨基乙基)氨基]苯并[g]喹啉-5,10-二酮
  参考文献：
  名称：

  6,9-二氟苯并[g]喹啉-5,10-二酮的合成。二胺置换氟化物，生成6,9-双[（氨基烷基）氨基]苯并[g]喹啉-5,10-二酮

  摘要：

  描述了6,9-二氟苯并[g]喹啉-5,10-二酮（3b）的合成。用二胺容易地从3b进行氟化物的异丙基取代，可轻松产生相应的6,9-双[（氨基烷基）氨基]苯并-[g]喹啉-5,10-二酮2。通过对二酮8a的侧臂修饰合成了类似物2d。

  DOI：

  10.1002/jhet.5570300619

文献信息

• COMPOSITION FOR INHIBITING OR PREVENTING THE FORMATION OF A BIOFILM
  申请人：Oystershell NV

  公开号：EP1796656A2

  公开（公告）日：2007-06-20
• Composition for Inhibiting or Preventing the Formation of a Biofilm
  申请人：Rossel Bart

  公开号：US20070258913A1

  公开（公告）日：2007-11-08

  Compounds for inhibiting and/or preventing the formation of a biofilm are disclosed. The compounds are an anthraquinone and/or a naphtoquinone, stereoisomeric forms, racemic mixtures, metabolites, esters or salts thereof, or mixtures thereof, and/or at least one plant extract including the compound or active fraction thereof. Compositions containing the compounds such as oral health products and methods of using the products in a method to prevent or inhibit biofilm formation are also disclosed. Preferred compositions include emodin and/or plant extracts from Rheum sp.
• US7691418B2
  申请人：——

  公开号：US7691418B2

  公开（公告）日：2010-04-06
• [EN] COMPOSITION FOR INHIBITING OR PREVENTING THE FORMATION OF A BIOFILM<br/>[FR] COMPOSITION PERMETTANT DE BLOQUER OU D'EMPECHER LA FORMATION D'UN FILM BIOLOGIQUE
  申请人：OYSTERSHELL NV

  公开号：WO2006029893A2

  公开（公告）日：2006-03-23

  The present invention provides the use of a compound selected from the group comprising an anthraquinone and a naphtoquinone, stereoisomeric forms, racemic mixtures, metabolites, esters or salts thereof, or mixtures thereof, and/or of at least one plant extract or active fraction thereof comprising said compound for preventing and/or inhibiting biofilm formation. The present invention further relates to compositions for preventing and/or inhibiting the formation of a biofilm, oral health products and a method for preventing and/or inhibiting biofilm formation.
• [EN] COMPOUNDS AND METHODS FOR TREATING CYSTIC FIBROSIS<br/>[FR] COMPOSÉS ET MÉTHODES DE TRAITEMENT D'UNE FIBROSE KYSTIQUE
  申请人：MARINE BIOLOGICAL LAB

  公开号：WO2013070911A1

  公开（公告）日：2013-05-16

  The invention features novel compounds useful for the treatment or prevention of cystic fibrosis. Further, the invention also relates to methods, kits and packaged compositions for the treatment or prevention of cystic fibrosis in a subject identified in need of a treatment of cystic fibrosis thereof. In particular embodiments, the compounds of the invention are capable of increasing CFTR expression level in a clinically significant amount in a cell membrane.