2-[(4-Methoxyphenyl)methylsulfanyl]-3-(2,3,4,5,6-pentafluorophenyl)prop-2-enamide

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: 2-[(4-Methoxyphenyl)methylsulfanyl]-3-(2,3,4,5,6-pentafluorophenyl)prop-2-enamide
• 英文别名: 2-[(4-methoxyphenyl)methylsulfanyl]-3-(2,3,4,5,6-pentafluorophenyl)prop-2-enamide
• 化学式: C₁₇H₁₂F₅NO₂S
• 分子量: 389.3
• InChiKey: YUGSFMWCMLZMNG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• ARYL VINYL SULFIDES, SULFONES, SULFOXIDES AND SULFONAMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF
  申请人：Temple University - of the Commonwealth System of Higher Education

  公开号：EP2046322A2

  公开（公告）日：2009-04-15
• Aryl Vinyl Sulfides, Sulfones, Sulfoxides and Sulfonamides, Derivatives Thereof and Therapeutic Uses Thereof
  申请人：Reddy E. Premkumar

  公开号：US20090191193A1

  公开（公告）日：2009-07-30

  Compounds useful as antiproliferative agents, including, for example, anticancer agents, according to formula I: wherein Ar 1 , Ar 2 , D, G, m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, synthetic processes, and intermediates useful in such processes are provided.
• [EN] ARYL VINYL SULFIDES, SULFONES, SULFOXIDES AND SULFONAMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF<br/>[FR] ARYL VINYL SULFURES, SULFONES, SULFOXIDES ET SULFONAMIDES, DÉRIVÉS DE CEUX-CI ET UTILISATIONS THÉRAPEUTIQUES DE CEUX-CI
  申请人：UNIV TEMPLE

  公开号：WO2008016682A2

  公开（公告）日：2008-02-07

  [EN] Compounds useful as antiproliferative agents, including, for example, anticancer agents, according to formula (I): wherein Ar¹, Ar², D, G, formula (a), m and n are as defined herein, salts, antibody conjugates, pharmaceutical compositions, methods of treatment, synthetic processes, and intermediates useful in such processes are provided.
  [FR] L'invention concerne des composés utiles comme agents anti-prolifératifs, comprenant, par exemple, des agents anti-cancer, selon la formule (I) : dans laquelle Ar¹, Ar², D, G, la formule (II), m et n sont tels que définis ici. L'invention concerne également des sels, des conjugués d'anticorps, des compositions pharmaceutiques, des procédés de traitement, des procédés de synthèse et des intermédiaires utiles dans de tels procédés.