3-(3-methylamino-propyl)-1-phenyl-3-propyl-3,4-dihydro-1H-quinolin-2-one | 792122-36-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 3-(3-methylamino-propyl)-1-phenyl-3-propyl-3,4-dihydro-1H-quinolin-2-one
• 英文别名: 3-[3-(methylamino)propyl]-1-phenyl-3-propyl-4H-quinolin-2-one
• CAS: 792122-36-2
• 化学式: C₂₂H₂₈N₂O
• 分子量: 336.477
• InChiKey: LQONCZWYZLNINV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-(3-methylamino-propyl)-1-phenyl-3-propyl-3,4-dihydro-1H-quinolin-2-one 生成 、
  参考文献：
  名称：

  [EN] QUINOLONE DERIVATIVES
  [FR] DERIVES DE QUINOLONE

  摘要：

  这项发明涉及到式(I)的化合物，其中-X-、n、R1、R3和Ar-具有本文中定义的值，它们的制备和用途作为去甲肾上腺素再摄取抑制剂，可用于治疗神经系统疾病。

  公开号：

  WO2004096773A1
• 作为产物：
  描述：

  3-(3-Hydroxy-propyl)-1-phenyl-3-propyl-3,4-dihydro-1H-quinolin-2-one 在 三乙胺 作用下， 以 四氢呋喃 、 乙醇 、 水 为溶剂， 反应 5.0h， 生成 3-(3-methylamino-propyl)-1-phenyl-3-propyl-3,4-dihydro-1H-quinolin-2-one
  参考文献：
  名称：

  1-Aryl-3,4-dihydro-1H-quinolin-2-one derivatives, novel and selective norepinephrine reuptake inhibitors

  摘要：

  A novel series of 1-aryl-3,4-dihydro-1H-quinolin-2-ones have been discovered as potent and selective norepinephrine reuptake inhibitors. Efficient synthetic routes have been developed which allow for the multi-gram preparation of both final targets and advanced intermediates for SAR expansion. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.07.038

文献信息

• Quinolone derivatives
  申请人：Camp Paul Nicholas

  公开号：US20070105845A1

  公开（公告）日：2007-05-10

  This invention relates to compounds of formula (I) where —X—, n, R 1 , R 3 and Ar— have the values defined herein, their preparation, and use as pharmaceuticals.

  本发明涉及式（I）化合物，其中—X—，n，R1，R3和Ar—具有在此定义的值，它们的制备以及用作药物的用途。
• 3,4-DIHYDRO-1H-QUINOLIN-2-ONE DERIVATIVES AS NOREPINEPHRINE REUPTAKE INHIBITORS
  申请人：ELI LILLY AND COMPANY

  公开号：EP1622874B1

  公开（公告）日：2007-10-03
• Treatment of hot flashes, impulse control disorders and personality change due to a general medical condition
  申请人：Allen John Albert

  公开号：US20070015786A1

  公开（公告）日：2007-01-18

  Selective norepinephrine reuptake inhibitors are useful for the prevention or treatment of hot flashes, vasomotor symptoms, impulse control disorders or personality change due to a general medical condition.
• Treatment of stuttering and other communication disorders with norepinephrine reuptake inhibitors
  申请人：Kelsey Kenneth Douglas

  公开号：US20070032554A1

  公开（公告）日：2007-02-08

  Provided are methods and medicaments for treating stuttering or another communication disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.
• Treatment of learning disabilities and motor skills disorder with norepinephrine reuptake inhibitors
  申请人：Sumner Russell Calvin

  公开号：US20070105960A1

  公开（公告）日：2007-05-10

  Provided are methods and medicaments for treating a learning disability or a Motor Skills Disorder, comprising administering to a patient in need of such treatment an effective amount of a selective norepinephrine reuptake inhibitor.