2'4'-Bis-benzyloxy-trans-chalkon | 4537-38-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 2'4'-Bis-benzyloxy-trans-chalkon
• 英文别名: 1-[2,4-Di(benzyloxy)phenyl]-3-phenylprop-2-en-1-one；(E)-1-[2,4-bis(phenylmethoxy)phenyl]-3-phenylprop-2-en-1-one
• CAS: 4537-38-6
• 化学式: C₂₉H₂₄O₃
• 分子量: 420.508
• InChiKey: XHJLHHXYYUYSIH-KNTRCKAVSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  32
• 可旋转键数：
  9
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(2,4-双(苄氧基)苯基)乙酮 、 苯甲醛 在 lithium hexamethyldisilazane 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 以48%的产率得到2'4'-Bis-benzyloxy-trans-chalkon
  参考文献：
  名称：

  Organolithium mediated synthesis of prenylchalcones as potential inhibitors of chemoresistance

  摘要：

  A number of substituted chalcones have been prepared by a novel LiHMDS-mediated aldol condensation, the first method consistent with the use of alkali-labile protecting groups such as tert-butyldiphenylsilyl or tert-butyldimethylsilyl. Chalcone substitution by prenylation increases their binding affinity to P-glycoprotein responsible for cancer cells chemoresistance. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(99)01461-6

文献信息

• Organolithium mediated synthesis of prenylchalcones as potential inhibitors of chemoresistance
  作者：Jean B. Daskiewicz、Gilles Comte、Denis Barron、Attilio Di Pietro、François Thomasson

  DOI：10.1016/s0040-4039(99)01461-6

  日期：1999.9

  A number of substituted chalcones have been prepared by a novel LiHMDS-mediated aldol condensation, the first method consistent with the use of alkali-labile protecting groups such as tert-butyldiphenylsilyl or tert-butyldimethylsilyl. Chalcone substitution by prenylation increases their binding affinity to P-glycoprotein responsible for cancer cells chemoresistance. (C) 1999 Elsevier Science Ltd. All rights reserved.